1-异丙基-4-(三氟甲基)苯合成路线 （共 16 条）
反应条件
hydrogen; palladium on activated charcoal in cyclohexane P=760 Torr; 3 h; Ambient temperature;
参考文献
Popielarz; Arnold
Journal of the American Chemical Society, 1990 , vol. 112, # 8 p. 3068 - 3082
反应条件
silver nitrate; 1-(chloromethyl)-4-fluoro-1,4-diazoniabicyclo-[2.2.2]octane bis(tetrafluoroborate) in water; acetone T=55°C; 1 h; Inert atmosphereSchlenk technique;
参考文献
Mizuta, Satoshi; Stenhagen, Ida S.R.; O'Duill, Miriam; Wolstenhulme, Jamie; Kirjavainen, Anna K.; Forsback, Sarita J.; Tredwell, Matthew; Sandford, Graham; Moore, Peter R.; Huiban, Mickael; Luthra, Sajinder K.; Passchier, Jan; Solin, Olof; Gouverneur, Veronique
Organic Letters, 2013 , vol. 15, # 11 p. 2648 - 2651
反应条件
1: 1.) NaH / 1.) diethyl ether, reflux, 3 h, 2.) reflux, overnight 2: 69 percent / H2 / 5percent Pd/C / cyclohexane / 3 h / 760 Torr / Ambient temperature View Scheme
参考文献
Popielarz; Arnold
Journal of the American Chemical Society, 1990 , vol. 112, # 8 p. 3068 - 3082
反应条件
acetic acid in methanol; pentane
参考文献
Merck and Co., Inc.
Patent: US5877191 A1, 1999 ;
US 5877191 A
反应条件
phosphorus; hydrogen iodide Heating;
参考文献
Arnold, Donald R.; Nicholas, A. Martin de P.; Snow, Miles S.
Canadian Journal of Chemistry, 1985 , vol. 63, p. 1150 - 1156
反应条件
1: potassium carbonate / methanol; water / 2 h / 20 °C / |Inert atmosphere 2: 1-(chloromethyl)-4-fluoro-1,4-diazoniabicyclo-[2.2.2]octane bis(tetrafluoroborate); silver nitrate / water; acetone / 1 h / 55 °C / |Inert atmosphere; |Schlenk technique View Scheme
参考文献
Mizuta, Satoshi; Stenhagen, Ida S.R.; O'Duill, Miriam; Wolstenhulme, Jamie; Kirjavainen, Anna K.; Forsback, Sarita J.; Tredwell, Matthew; Sandford, Graham; Moore, Peter R.; Huiban, Mickael; Luthra, Sajinder K.; Passchier, Jan; Solin, Olof; Gouverneur, Veronique
Organic Letters, 2013 , vol. 15, # 11 p. 2648 - 2651
反应条件
1: copper / dimethyl sulfoxide / 12 h / 60 °C / |Inert atmosphere 2: potassium carbonate / methanol; water / 2 h / 20 °C / |Inert atmosphere 3: 1-(chloromethyl)-4-fluoro-1,4-diazoniabicyclo-[2.2.2]octane bis(tetrafluoroborate); silver nitrate / water; acetone / 1 h / 55 °C / |Inert atmosphere; |Schlenk technique View Scheme
参考文献
Mizuta, Satoshi; Stenhagen, Ida S.R.; O'Duill, Miriam; Wolstenhulme, Jamie; Kirjavainen, Anna K.; Forsback, Sarita J.; Tredwell, Matthew; Sandford, Graham; Moore, Peter R.; Huiban, Mickael; Luthra, Sajinder K.; Passchier, Jan; Solin, Olof; Gouverneur, Veronique
Organic Letters, 2013 , vol. 15, # 11 p. 2648 - 2651
反应条件
hydrogen fluoride T=15°C;
参考文献
Marhold, A.; Klauke, E.
Journal of Fluorine Chemistry, 1985 , vol. 29, p. 117
反应条件
1: Ag2CO3-SiO2 2: pentane / Irradiation View Scheme
参考文献
Kuentzel,H. et al.
Helvetica Chimica Acta, 1971 , vol. 54, p. 868 - 897
反应条件
1: aq. NaOH 2: LiAlH4 3: Ag2CO3-SiO2 4: pentane / Irradiation View Scheme
参考文献
Kuentzel,H. et al.
Helvetica Chimica Acta, 1971 , vol. 54, p. 868 - 897
