(αS,γS,δS,ζS)-N-(3-氨基-2,2-二甲基-3-氧代丙基)-δ-叠氮-γ-羟基-4-甲氧基-3-(3-甲氧基丙氧基)-α, ζ-二异丙基-苯辛酰胺合成路线 （共 55 条）
反应条件
1: propionic acid / 2 h / 110 °C 2: triethylamine / dichloromethane / 0.33 h / 20 °C 3: triethylamine / 1,2-dichloro-ethane / 21 h / 80 °C 4: water; dihydrogen peroxide; lithium hydroxide hydrate / tetrahydrofuran / 144 h / 55 °C View Scheme
参考文献
Kim, Ji Hei; Ko, Soo Y.
Bulletin of the Korean Chemical Society, 2013 , vol. 34, # 12 p. 3777 - 3781
反应条件
1: 85 percent / NaN3; 15-crown-6; DMPU 2: 59 percent / 2-OH-pyridine; NEt3 View Scheme
参考文献
Rueger; Stutz; Goschke; Spindler; Maibaum
Tetrahedron Letters, 2000 , vol. 41, # 51 p. 10085 - 10089
反应条件
1: NaN3; NMP / 60 °C 2: 76 percent / 2-hydroxypyridine; Et3N / 80 °C View Scheme
参考文献
Sandham; Taylor; Carey; Fassler
Tetrahedron Letters, 2000 , vol. 41, # 51 p. 10091 - 10094
反应条件
hydrogenchloride; hydrogen; palladium on activated charcoal in methanol
参考文献
Tetrahedron Letters, , vol. 41, # 51 p. 10085 - 10089
反应条件
1: (2S,4S,5S,7S)-N-(3-amino-2,2-dimethyl-3-oxopropyl)-5-azido-4-hydroxy-2-isopropyl-7-(4-methoxy-3-(methoxypropoxy)benzyl)-8-methylnonanamide With hydrogen; ethanolamine; 5 palladium on charcoal in ethanol P=2206.72 Torr; 2: (2E)-but-2-enedioic acid in ethanol Product distribution / selectivity;
参考文献
MATRIX LABORATORIES LTD; RAMA, Shankar; VADALI, Lakshmana Rao; PALLA, Vijay Kumar; SAIDUGARI, Swamy; MITTAPELLY, Nagaraju; JALDU, Ravikanth; VIJAYA, Krishna Ravi; SESHADRI, Rao Manukonda; DASARL, Srinivasa Rao; SRINIVASA, Rao Potla; DANDALA, Ramesh
Patent: WO2012/52829 A1, 2012 ;
Location in patent: Page/Page column 16-17 ;
