3-氨基-2,2-二甲基丙酰胺合成路线 （共 34 条）
反应条件
1: With ammonia; Raney nickel in methanol T=25 - 35°C; Autoclave; 2: With hydrogen in methanol T=60 - 65°C; P=5149.01 - 5884.58 Torr; 10 h;
参考文献
DR. REDDY'S LABORATORIES LTD.; DR. REDDY'S LABORATORIES, INC.; KOLLA, Naveen Kumar; APPAYE, Kaliyaperumal Srinivasan; GANGULA, Srinivas; GOVINDAPUR, Rajeshwar Reddy; MANNE, Nagaraju; NIKUMBH, Satish Pandurang; NEELAM, Uday Kumar; JOSEPH, Suju Chuttippari; BADDAM, Sudhakar Reddy; KUNHIMON, Shyam Kumar Unniaranpurakkal; MOOVENDAN, Mohan; DAHANUKAR, Vilas; DONIPARTHI, Kiran Kumar
Patent: WO2012/21446 A2, 2012 ;
Location in patent: Page/Page column 30-31 ;
反应条件
hydrogen; palladium-carbon in ethanol T=20°C; 2 h;
参考文献
Daiichi Sankyo Company, Limited
Patent: EP2036896 A1, 2009 ;
Location in patent: Page/Page column 148-149 ;
反应条件
ammonia in methanol T=60°C; P=3750.38 Torr; 48 h; Autoclave;
参考文献
Sandoz AG; ALBERT, Martin; DE SOUZA, Dominic; LANGNER, Martin
Patent: WO2012/10651 A2, 2012 ;
Location in patent: Page/Page column 19-20 ;
反应条件
hydrogen; Raney-Nickel in 2-methyl-propan-1-ol T=55 - 65°C; P=750.075 Torr; Inert atmosphereSealed tube;
参考文献
WO2011/12319 A1, ;
Page/Page column 23 ;
反应条件
ammonia; sodium methylate in methanol T=60°C; 50 h; Autoclave;
参考文献
Sandoz AG; ALBERT, Martin; DE SOUZA, Dominic; LANGNER, Martin
Patent: WO2012/10651 A2, 2012 ;
Location in patent: Page/Page column 18 ;
反应条件
1: With ammonia; hydrogen; nickel in 1-methyl-pyrrolidin-2-one; water T=80°C; P=3750.38 Torr; 1.5 h; 2: With ammonia; hydrogen; nickel in 1-methyl-pyrrolidin-2-one; water T=80°C; P=150015 Torr; Product distribution / selectivity;
参考文献
US2008/306299 A1, ;
Page/Page column 4 ;
反应条件
ammonia; hydrogen; mixture of 28percent NiO, 28percent CoO, 13percent CuO, 31percent ZrO2; hydrogenated in methanol T=100°C; P=150015 Torr; Product distribution / selectivity;
参考文献
US2008/306299 A1, ;
Page/Page column 4-5 ;
反应条件
1: ammonia / methanol / 12 h / 25 - 30 °C 2: hydrogen; ammonia / raney nickel / methanol / 14 h / 40 - 45 °C / 2942.29 Torr View Scheme
反应条件
1: ammonia / dichloromethane / 2.75 h / 20 °C / Cooling with ice 2: sodium methylate; ammonia / methanol / 50 h / 60 °C / Autoclave View Scheme
反应条件
1: hydrogen bromide / water / 19 h / 100 °C 2: ammonia / 1,4-dioxane / 16 h / 60 °C / 2250.23 Torr / Autoclave 3: hydrogenchloride / 20 h / 20 °C 4: ammonia / methanol / 48 h / 60 °C / 3750.38 Torr / Autoclave View Scheme
