3-氨基-2,2-二甲基丙酰胺合成路线 （共 34 条）
反应条件
1: hydrogenchloride / 20 h / 20 °C 2: ammonia / methanol / 48 h / 60 °C / 3750.38 Torr / Autoclave View Scheme
反应条件
1: ammonia / 1,4-dioxane / 16 h / 60 °C / 2250.23 Torr / Autoclave 2: hydrogenchloride / 20 h / 20 °C 3: ammonia / methanol / 48 h / 60 °C / 3750.38 Torr / Autoclave View Scheme
反应条件
methanol; Lindlar's catalyst Hydrogenation;
参考文献
Journal of the Chemical Society, , p. 1502
Chem.Abstr., , p. 770
反应条件
T=100°C; Hydrogenation;
参考文献
US2428614 , ;
Journal of the Chemical Society, , p. 1502
Chem.Abstr., , p. 770
参考文献
US2428614 , ;
Journal of the Chemical Society, , p. 1502
Chem.Abstr., , p. 770
参考文献
US2428614 , ;
Journal of the Chemical Society, , p. 1502
Chem.Abstr., , p. 770
反应条件
1: sodium azide; (3S,5S)-5-{(1R,3S)-1-bromo-3-{[4-methoxy-3-(3-methoxypropoxy)phenyl]methyl}-4-methylpentyl}-dihydro-3-(1-methylethyl)furan-2(3H)-one in N,N'-dimethyl-N,N'-propyleneurea T=75 - 80°C; 4 h; 2: 3-amino-2,2-dimethylpropionic acid amide With 2-hydroxy-pyridine; triethylamine T=85 - 90°C; 15 h; 3: With hydrogen; palladium on activated charcoal in isopropyl alcohol 3 h;
参考文献
WO2011/148392 A1, ;
Page/Page column 55-56 ;
反应条件
2-hydroxy-pyridine; triethylamine T=65°C;
参考文献
WO2010/10165 A1, ;
Page/Page column 49 ;
反应条件
1: triethylamine; 2-hydroxy-pyridine / 16 h / 85 - 90 °C 2: hydrogen; ethanolamine / palladium 10 on activated carbon / isopropyl alcohol / 3 h View Scheme
反应条件
1: 65 percent / 2-hydroxypyridine; Et3N 2: TMSCl; phenol / CH2Cl2 View Scheme
参考文献
Tetrahedron Letters, , vol. 46, # 37 p. 6337 - 6340
