3-氨基-2,2-二甲基丙酰胺合成路线 （共 34 条）
反应条件
1.1: triethylamine; 2-hydroxy-pyridine 2.1: hydrogenchloride / water; acetone / 20 °C 2.2: pH 8 - 9 View Scheme
反应条件
1: 2-hydroxy-pyridine; triethylamine / toluene / 16 h / |Reflux; |Inert atmosphere 2: 5 palladium on charcoal; hydrogen / tert-butyl methyl ether / 16 h / 25 °C / 2280.15 Torr View Scheme
反应条件
1: aqueous H2SO4 2: HCl View Scheme
参考文献
Buckley; Heath; Rose
Journal of the Chemical Society, 1947 , p. 1502
Chem.Abstr., 1948 , p. 770
参考文献
AUSPEX PHARMACEUTICALS, INC.
Patent: US2010/124550 A1, 2010 ;
US 20100124550 A1
反应条件
2-hydroxy-pyridine; triethylamine T=85 - 90°C; 16 h;
参考文献
MSN LABORATORIES LIMITED; SATYANARAYANA REDDY, Manne; THIRUMALAI RAJAN, Srinivasan; ESWARAIAH, Sajja; VENKAT REDDY, Ghojala; RAMA SUBBA REDDY, Karamala; SAHADEVA REDDY, Maramreddy
Patent: WO2011/148392 A1, 2011 ;
Location in patent: Page/Page column 53-54 ;
反应条件
2-hydroxy-pyridine; triethylamine T=80°C;
参考文献
Sandham; Taylor; Carey; Fassler
Tetrahedron Letters, 2000 , vol. 41, # 51 p. 10091 - 10094
反应条件
1.1: thionyl chloride / 1,2-dichloro-ethane / 5 h / 75 - 80 °C 1.2: 90 - 95 °C 1.3: 10 - 15 °C / pH 14 2.1: triethylamine; 2-hydroxy-pyridine / 30 h / 80 - 90 °C 3.1: sodium hydroxide; dihydrogen peroxide / water / 20 - 40 °C View Scheme
参考文献
MATRIX LABORATORIES LTD; RAMA, Shankar; VADALI, Lakshmana Rao; PALLA, Vijay Kumar; SAIDUGARI, Swamy; MITTAPELLY, Nagaraju; JALDU, Ravikanth; VIJAYA, Krishna Ravi; SESHADRI, Rao Manukonda; DASARL, Srinivasa Rao; SRINIVASA, Rao Potla; DANDALA, Ramesh
Patent: WO2012/52829 A1, 2012 ;
反应条件
2-ethyl-1-hexanoic acid in di-isopropyl ether T=60°C; SolventReagent/catalyst;
参考文献
CHEMO IBERICA, S. A.; CARCONE, Luca; MAGRONE, Domenico; BARRECA, Giuseppe; RASPARINI, Marcello; LI MING, Huan
Patent: WO2013/14191 A1, 2013 ;
Location in patent: Page/Page column 17; 18 ;
反应条件
2-hydroxy-pyridine in tert-butyl methyl ether T=65°C;
参考文献
Slade, Joel; Liu, Hui; Prashad, Mahavir; Prasad, Kapa
Tetrahedron Letters, 2011 , vol. 52, # 33 p. 4349 - 4352
参考文献
Buckley; Heath; Rose
Journal of the Chemical Society, 1947 , p. 1502
Chem.Abstr., 1948 , p. 770
