1-BOC-3,3-二甲基-4-氧代哌啶合成路线 （共 12 条）
反应条件
hydrogen; palladium 10 on activated carbon in methanol T=20°C; P=3345.86 Torr; 16 h;
参考文献
ELI LILLY AND COMPANY
Patent: EP1204660 B1, 2004 ;
Location in patent: Page 18 ;
反应条件
1: tert-butyl 4-oxo-piperidine-1-carboxylate With sodium hydride in tetrahydrofuran T=0°C; 0.5 h; 2: methyl iodide in tetrahydrofuran T=23°C; 48 h;
参考文献
SCHERING CORPORATION
Patent: US2005/182095 A1, 2005 ;
Location in patent: Page/Page column 64 ;
US 20050182095 A1
反应条件
sodium hydride in tetrahydrofuran T=10°C; 0.5 h;
参考文献
ACTELION PHARMACEUTICALS LTD
Patent: WO2005/40120 A1, 2005 ;
Location in patent: Page/Page column 25 ;
WO 2005/040120 A1
反应条件
sodium hydride; methyl iodide in tetrahydrofuran T=0 - 20°C;
参考文献
BRISTOL-MYERS SQUIBB COMPANY
Patent: WO2003/104236 A1, 2003 ;
Location in patent: Page 158 ;
WO 03/104236 A1
反应条件
triethylamine in dichloromethane
参考文献
Wockhardt Limited
Patent: US6878713 B2, 2005 ;
反应条件
1: conc. HCl / ethanol 2: H2 / 10 percent Pd/C / ethanol View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 13, # 10 p. 1627 - 1629
反应条件
sodium tetrahydroborate in ethanol T=0 - 20°C;
参考文献
KHAMRAI, Uttam; Karak, Sumit Kumar; Ronsheim, Matthew; Saha, Ashis Kumar
Patent: US2010/168080 A1, 2010 ;
Location in patent: Page/Page column 63 ;
反应条件
1: With sodium tris(acetoxy)borohydride in tetrahydrofuran T=20°C; 1 h; 2: With acetic acid in tetrahydrofuran 3: With sodium hydrogencarbonate in tetrahydrofuran; water; ethyl acetate
参考文献
AMGEN INC.
Patent: WO2007/67629 A1, 2007 ;
Location in patent: Page/Page column 65 ;
WO 2007/067629 A1
反应条件
trifluoroacetic acid in dichloromethane
T=20°C; 3 h;
参考文献
SEPRACOR INC.; BURDI, Douglas; SPEAR, Kerry, L.; HARDY, Larry, Wendell
Patent: WO2010/114971 A1, 2010 ;
Location in patent: Page/Page column 219 ;
反应条件
hydrogenchloride in tetrahydrofuran
T=20 - 60°C; 3 h;
参考文献
HELSINN HEALTHCARE S.A.; GARCIA RUBIO, Silvina; PIETRA, Claudio; GIULIANO, Claudio; LI, Zhigang
Patent: WO2012/113103 A1, 2012 ;
Location in patent: Page/Page column 61 ;
WO 2012/113103 A1
