1: 1.) N-ethylmorpholine, isobutyl chloroformate / 1.) THF, -15 deg C, 5 min; 2.) THF/EtOH, -15 deg C to rt., 20 min 2: H2 / 5percent Pd/C / aq. acetic acid / Ambient temperature 3: pyridine / 0.25 h / -15 °C View Scheme

1: H2 / 5percent Pd/C / aq. acetic acid / Ambient temperature 2: pyridine / 0.25 h / -15 °C View Scheme

methanol

in pyridine T=-15°C; 0.25 h; Yield given;

(i) ClCO2Et, N-methylmorpholine, THF, (ii) /BRN= 741851/, H2O; Multistep reaction;