(2S,4E,7R)-7-[[4-甲氧基-3-(3-甲氧基丙氧基)苯基]甲基]-N,N,8-三甲基-2-异丙基-4-壬烯酰胺合成路线 (共 3 条)
反应条件
1: N-bromosuccinmide; phosphoric acid / water; tetrahydrofuran / 5 °C 2: sodium azide; Aliquatreg; 336 / water / 48 h / 75 - 80 °C View Scheme
反应条件
1: N-bromosuccinmide; phosphoric acid / water; tetrahydrofuran / 1.25 h / 0 - 5 °C 2: sodium azide / ethylene glycol / 20 h / 80 - 85 °C 3: triethylamine; 2-hydroxy-pyridine / 16 h / 85 - 90 °C 4: hydrogen; ethanolamine / palladium 10 on activated carbon / isopropyl alcohol / 3 h View Scheme
反应条件
1: N-bromosuccinmide; phosphoric acid / water; tetrahydrofuran / 1.25 h / 0 - 5 °C 2: sodium azide / ethylene glycol / 20 h / 80 - 85 °C 3: triethylamine; 2-hydroxy-pyridine / 16 h / 85 - 90 °C View Scheme
参考文献
MATRIX LABORATORIES LTD; RAMA, Shankar; VADALI, Lakshmana Rao; PALLA, Vijay Kumar; SAIDUGARI, Swamy; MITTAPELLY, Nagaraju; JALDU, Ravikanth; VIJAYA, Krishna Ravi; SESHADRI, Rao Manukonda; DASARL, Srinivasa Rao; SRINIVASA, Rao Potla; DANDALA, Ramesh
Patent: WO2012/52829 A1, 2012 ;