L-erythro-4-氟谷氨酸合成路线 （共 14 条）
反应条件
1: With hydrogenchloride in water 4 h; Heating; 2: With methyloxirane in ethanol T=0°C; 0.333333 h; Further stages.;
参考文献
Konas; Coward
Journal of Organic Chemistry, 2001 , vol. 66, # 26 p. 8831 - 8842
反应条件
1: diethylaminosulfur trifluoride (DAST) / CH2Cl2 / 4 h 2: 62.5 percent / ruthenium tetraoxide / ethyl acetate; H2O / 62.5 h 3: 16.1 percent / conc. HCl / 4 h / Heating View Scheme
参考文献
Journal of Fluorine Chemistry, , vol. 60, # 2.3 p. 193 - 210
反应条件
1: 47 percent / acetonitrile / 2 h / Heating 2: aq. NH3, porcine kidney aminoacylase / 3 h / 28 °C / pH 6.0 3: Dowex 50W-X8, aq. NH3 View Scheme
参考文献
Tetrahedron Asymmetry, , vol. 7, # 12 p. 3545 - 3551
反应条件
hydrogenchloride 4 h; Heating;
参考文献
Hudlicky, M.
Journal of Fluorine Chemistry, 1993 , vol. 60, # 2.3 p. 193 - 210
反应条件
1: 62.5 percent / ruthenium tetraoxide / ethyl acetate; H2O / 62.5 h 2: 16.1 percent / conc. HCl / 4 h / Heating View Scheme
参考文献
Journal of Fluorine Chemistry, , vol. 60, # 2.3 p. 193 - 210
反应条件
1: 2-chloro-1,1,2-trifluorotriethylamine / CH2Cl2 / 16.5 h / Ambient temperature 2: 62.5 percent / ruthenium tetraoxide / ethyl acetate; H2O / 62.5 h 3: 16.1 percent / conc. HCl / 4 h / Heating View Scheme
参考文献
Journal of Fluorine Chemistry, , vol. 60, # 2.3 p. 193 - 210
反应条件
magnesium sulfate T=37°C; 5.5 h; Tris buffer (pH 9), leucine aminopeptidase;
参考文献
Bory, Sonia; Dubois, Joelle; Gaudry, Michel; Marquet, Andree; Lacombe, Liliane; Weinstein, Shulamith
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1984 , # 3 p. 475 - 480
反应条件
magnesium sulfate T=36°C; 3.5 h; Tris buffer (pH 9), leucine aminopeptidase;
参考文献
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , # 3 p. 475 - 480
反应条件
1: 1.) Et3N, 2.) CF3CO2H / 1.) H2O, room temperature, 2 h, 2.) CH2Cl2, 2.5 h 2: 278 mg / MgSO4 / 3.5 h / 36 °C / Tris buffer (pH 9), leucine aminopeptidase View Scheme
参考文献
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , # 3 p. 475 - 480
反应条件
2: 1) DAST, 2) RuO4 3: 1) HCl, 2) Ag2O View Scheme
参考文献
Journal of Fluorine Chemistry, , vol. 54, # 1-3 p. 195
