4-氯-6-羟基甲基-2-苯基嘧啶合成路线 （共 5 条）
反应条件
1: With boron tribromide in dichloromethane T=-12 - 0°C; 3 h; 2: With water in diethyl ether; dichloromethane T=20°C; 2 h; Further stages.;
参考文献
Gardinier, Kevin M.; Khoury, Richard G.; Lehn, Jean-Marie
Chemistry - A European Journal, 2000 , vol. 6, # 22 p. 4124 - 4131
反应条件
1.1: 29.0 g / POCl3 / 3 h / Heating 2.1: BBr3 / CH2Cl2 / 3 h / -12 - 0 °C 2.2: 99 percent / H2O / diethyl ether; CH2Cl2 / 2 h / 20 °C View Scheme
参考文献
Gardinier, Kevin M.; Khoury, Richard G.; Lehn, Jean-Marie
Chemistry - A European Journal, 2000 , vol. 6, # 22 p. 4124 - 4131
反应条件
1.1: NaOMe / methanol; ethanol / 21 h / Heating 2.1: 29.0 g / POCl3 / 3 h / Heating 3.1: BBr3 / CH2Cl2 / 3 h / -12 - 0 °C 3.2: 99 percent / H2O / diethyl ether; CH2Cl2 / 2 h / 20 °C View Scheme
参考文献
Gardinier, Kevin M.; Khoury, Richard G.; Lehn, Jean-Marie
Chemistry - A European Journal, 2000 , vol. 6, # 22 p. 4124 - 4131
反应条件
2,2,6,6-tetramethyl-1-piperidinyloxy, free radical; trichloroisocyanuric acid; sodium hydrogencarbonate; sodium bromide in water; acetone T=5 - 20°C;
参考文献
Actelion Pharmaceuticals Ltd.
Patent: EP2079711 B1, 2010 ;
Location in patent: Page/Page column 20 ;
反应条件
in ethanol
48 h; Heating;
参考文献
Giuseppone, Nicolas; Schmitt, Jean-Louis; Lehn, Jean-Marie
Journal of the American Chemical Society, 2006 , vol. 128, # 51 p. 16748 - 16763
