4-异丙基-5-氧代四氢-2-呋喃甲酰氯合成路线 （共 3 条）
反应条件
1: NEt3 / CH2Cl2 2: 100 percent / H2 / Pd/C / ethyl acetate 3: (COCl)2 / toluene; dimethylformamide / 1 h 4: Mg; BrCH2CH2Br / tetrahydrofuran / 20 °C 5: H2 / [Ru2Cl4((S)-BINAP)]NEt3 / methanol / 40 h / 40 °C / 37503 Torr 6: NEt3 / CH2Cl2 7: 85 percent / NaN3; 15-crown-6; DMPU View Scheme
参考文献
Tetrahedron Letters, , vol. 41, # 51 p. 10085 - 10089
反应条件
1: NEt3 / CH2Cl2 2: 100 percent / H2 / Pd/C / ethyl acetate 3: (COCl)2 / toluene; dimethylformamide / 1 h 4: Mg; BrCH2CH2Br / tetrahydrofuran / 20 °C 5: H2 / [Ru2Cl4((S)-BINAP)]NEt3 / methanol / 40 h / 40 °C / 37503 Torr 6: NEt3 / CH2Cl2 7: 85 percent / NaN3; 15-crown-6; DMPU 8: 59 percent / 2-OH-pyridine; NEt3 9: H2; aq. HCl / Pd/C / methanol View Scheme
参考文献
Tetrahedron Letters, , vol. 41, # 51 p. 10085 - 10089
反应条件
1: NEt3 / CH2Cl2 2: 100 percent / H2 / Pd/C / ethyl acetate 3: (COCl)2 / toluene; dimethylformamide / 1 h 4: Mg; BrCH2CH2Br / tetrahydrofuran / 20 °C 5: H2 / [Ru2Cl4((S)-BINAP)]NEt3 / methanol / 40 h / 40 °C / 37503 Torr 6: NEt3 / CH2Cl2 7: 85 percent / NaN3; 15-crown-6; DMPU 8: 59 percent / 2-OH-pyridine; NEt3 View Scheme
参考文献
Rueger; Stutz; Goschke; Spindler; Maibaum
Tetrahedron Letters, 2000 , vol. 41, # 51 p. 10085 - 10089
