(S)-2-乙氧基-3-(4-羟基苯基)-丙酸合成路线 （共 17 条）
反应条件
esterase from aspergillus oryzae in aq. phosphate buffer Large scaleEnzymatic reaction;
参考文献
Deussen, Heinz-Josef; Jeppesen, Lone; Schaerer, Norbert; Junager, Finn; Bentzen, Bjorn; Weber, Beat; Weil, Volker; Mozer, Sandor Josef; Sauerberg, Per
Organic Process Research and Development, 2004 , vol. 8, # 3 p. 363 - 371
反应条件
sodium hydroxide in water; ethyl acetate
参考文献
AstraZeneca AB
Patent: US6531622 B1, 2003 ;
反应条件
1: 92 percent / t-BuOK / 2-methyl-propan-2-ol; various solvent(s) / 0.5 h / 15 °C 2: 99 percent / H2 / 5 percent Pd/C / various solvent(s) / 20 °C / atmospheric pressure 3: 39 percent / Pectinex Ultra SP-L enzyme; aq. phosphate buffer / 44 h / 20 °C / pH 7.0 View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 46, # 8 p. 1306 - 1317
反应条件
1: 99 percent / H2 / 5 percent Pd/C / various solvent(s) / 20 °C / atmospheric pressure 2: 39 percent / Pectinex Ultra SP-L enzyme; aq. phosphate buffer / 44 h / 20 °C / pH 7.0 View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 46, # 8 p. 1306 - 1317
反应条件
hydrogen iodide in water
参考文献
Organic Process Research and Development, , vol. 8, # 6 p. 838 - 845
反应条件
1: With ethyl mercaptan sodium salt in N,N-dimethyl-formamide; mineral oil T=130°C; 48 h; Inert atmosphere; 2: With hydrogenchloride in water; N,N-dimethyl-formamide; mineral oil
参考文献
Tetrahedron Asymmetry, , vol. 20, # 22 p. 2594 - 2599
反应条件
n-octanethiol; water; sodium hydroxide in 1-methyl-pyrrolidin-2-one; toluene T=125°C; 19 h;
参考文献
Linderberg, Mats T.; Moge, Mikael; Sivadasan, Sivaprasad
Organic Process Research and Development, 2004 , vol. 8, # 6 p. 838 - 845
反应条件
α-chymotrypsins from bovine pancreas in aq. buffer T=20°C; Resolution of racemateEnzymatic reaction; enantioselective reaction;
参考文献
Organic Process Research and Development, , vol. 7, # 1 p. 82 - 88
反应条件
sulfuric acid in 1,4-dioxane; water T=90°C; 5 h;
参考文献
US6362360 B1, ;
Example 2 ;
反应条件
1: hydrogen; 5 palladium on charcoal / isopropanol acetate / 3 h / 22 - 25 °C / 3000.3 Torr / |Autoclave; |Inert atmosphere 2: isopropanol acetate / 0.17 h / 45 - 47 °C 3: sodium octyl mercaptide / 1-methyl-pyrrolidin-2-one / 120 - 170 °C View Scheme
参考文献
Organic Process Research and Development, , vol. 8, # 6 p. 838 - 845
