(S)-2-乙氧基-3-(4-羟基苯基)-丙酸合成路线 （共 17 条）
反应条件
Aspergillus oryzae hydrolytic enzyme mixture in aq. phosphate buffer T=20°C; pH=7; 16 h; Resolution of racemateLarge scaleEnzymatic reaction; Catalytic behavior; Reagent/catalystTimeConcentrationSolvent; enantioselective reaction;
参考文献
Deussen, Heinz-Josef; Zundel, Magali; Valdois, Marine; Lehmann, Soren Vig; Weil, Volker; Mailand Hjort, Carsten; stergaard, Peter Rahbek; Marcussen, Erik; Ebdrup, Soren
Organic Process Research and Development, 2003 , vol. 7, # 1 p. 82 - 88
反应条件
1: hydrogen; acetic acid / ethanol / 1500.15 - 4500.45 Torr 2: Aspergillus oryzae hydrolytic enzyme mixture / aq. phosphate buffer / 16 h / 20 °C / pH 7 / |Resolution of racemate; |Large scale; |Enzymatic reaction View Scheme
参考文献
Organic Process Research and Development, , vol. 7, # 1 p. 82 - 88
反应条件
1: hydrogen; acetic acid / ethanol / 1500.15 - 4500.45 Torr 2: protease 1 (aspergillopepsin II) preparation from Aspergillus aculeatus / aq. buffer / 20 °C / |Resolution of racemate; |Large scale; |Enzymatic reaction View Scheme
参考文献
Organic Process Research and Development, , vol. 7, # 1 p. 82 - 88
反应条件
1: hydrogen; 5 palladium on charcoal / isopropanol acetate / 3 h / 22 - 25 °C / 3000.3 Torr / |Autoclave; |Inert atmosphere 2: isopropanol acetate / 0.17 h / 45 - 47 °C 3: hydrogen iodide / water View Scheme
参考文献
Organic Process Research and Development, , vol. 8, # 6 p. 838 - 845
反应条件
protease 1 (aspergillopepsin II) preparation from Aspergillus aculeatus in aq. buffer T=20°C; Resolution of racemateLarge scaleEnzymatic reaction; Catalytic behavior; Reagent/catalyst; enantioselective reaction;
参考文献
Organic Process Research and Development, , vol. 7, # 1 p. 82 - 88
反应条件
water; sodium hydroxide T=95°C; pH=10.0; Kinetics; pH-valueConcentration;
参考文献
Organic Process Research and Development, , vol. 12, # 2 p. 213 - 217
反应条件
thionyl chloride 3 h; Heating / reflux;
参考文献
WO2008/108602 A1, ;
Page/Page column 45; 27 ;
