1-(5-甲氧基-2-吡啶)乙酮合成路线 （共 6 条）
反应条件
1: in tetrahydrofuran T=-78 - -40°C; 2 h; 2: With ammonium chloride in tetrahydrofuran; water
参考文献
Brewster, William Kirkland; Klittich, Carla Jean Rasmussen; Balko, Terry William; Breaux, Nneka Tuere; Erickson, William Randal; Hunter, James Edward; Lowe, Christian Thomas; Ricks, Michael John; Siddall, Thomas Lyman; Yerkes, Carla Nanette; Zhu, Yuanming
Patent: US2006/89370 A1, 2006 ;
Location in patent: Page/Page column 33-34 ;
反应条件
1: 2-bromo-5-methoxypyridine With n-butyllithium in tetrahydrofuran; hexane T=-105 - -100°C; 2: 1-acetyl-3-indolecarboxaldehyde in tetrahydrofuran; hexane T=-100°C;
参考文献
Reimann; Erdle
Pharmazie, 2000 , vol. 55, # 12 p. 907 - 912
反应条件
1.1: 80 percent / conc. H2SO4; fum. HNO3 / 4 h / 50 °C 2.1: 95 percent / N2H4*H2O / 5 percent Pd/C / ethanol / 1.5 h / Heating 3.1: Br2 / aq. HBr / cooling 3.2: 67 percent / aq. NaNO2 / 0.5 h / cooling 4.1: BuLi / tetrahydrofuran; hexane / -105 - -100 °C 4.2: tetrahydrofuran; hexane / -100 °C View Scheme
参考文献
Reimann; Erdle
Pharmazie, 2000 , vol. 55, # 12 p. 907 - 912
反应条件
1.1: 95 percent / N2H4*H2O / 5 percent Pd/C / ethanol / 1.5 h / Heating 2.1: Br2 / aq. HBr / cooling 2.2: 67 percent / aq. NaNO2 / 0.5 h / cooling 3.1: BuLi / tetrahydrofuran; hexane / -105 - -100 °C 3.2: tetrahydrofuran; hexane / -100 °C View Scheme
参考文献
Reimann; Erdle
Pharmazie, 2000 , vol. 55, # 12 p. 907 - 912
反应条件
n-butyllithium T=-40 - 23°C;
参考文献
Garbaccio, Robert M.; Brnardic, Edward J.; Fraley, Mark E.; Hartman, George D.; Hutson, Pete H.; O'Brien, Julie A.; Magliaro, Brian C.; Uslaner, Jason M.; Huszar, Sarah L.; Fillgrove, Kerry L.; Small, James H.; Tang, Cuyue; Kuo, Yuhsin; Jacobson, Marlene A.
ACS Medicinal Chemistry Letters, 2010 , vol. 1, # 8 p. 406 - 410
反应条件
1.1: Br2 / aq. HBr / cooling 1.2: 67 percent / aq. NaNO2 / 0.5 h / cooling 2.1: BuLi / tetrahydrofuran; hexane / -105 - -100 °C 2.2: tetrahydrofuran; hexane / -100 °C View Scheme
参考文献
Reimann; Erdle
Pharmazie, 2000 , vol. 55, # 12 p. 907 - 912
