3-氨基吡嗪-2-甲酰胺合成路线 （共 24 条）
反应条件
1: 58 percent / 3.5 h / 105 °C 2: 47 percent / aq. HCl / 1.5 h / Ambient temperature 3: 5percent NaOH / H2O / 0.58 h / Ambient temperature View Scheme
参考文献
Tetrahedron, , vol. 39, # 5 p. 823 - 829
反应条件
1: 80 percent / aq. HCl / Ambient temperature 2: 5percent NaOH / H2O / 0.58 h / Ambient temperature View Scheme
参考文献
Tetrahedron, , vol. 39, # 5 p. 823 - 829
反应条件
1: hydroxylamine hydrochloride / methanol / 0.5 h / Ambient temperature 2: 71 percent / aq. HCl 3: 5percent NaOH / H2O / 0.58 h / Ambient temperature View Scheme
参考文献
Tetrahedron, , vol. 39, # 5 p. 823 - 829
反应条件
1: 47 percent / aq. HCl / 1.5 h / Ambient temperature 2: 5percent NaOH / H2O / 0.58 h / Ambient temperature View Scheme
参考文献
Tetrahedron, , vol. 39, # 5 p. 823 - 829
反应条件
1: 71 percent / aq. HCl 2: 5percent NaOH / H2O / 0.58 h / Ambient temperature View Scheme
参考文献
Tetrahedron, , vol. 39, # 5 p. 823 - 829
反应条件
sodium hydroxide in water 1.25 h; Ambient temperature; Title compound not separated from byproducts;
参考文献
Tetrahedron, , vol. 39, # 5 p. 823 - 829
反应条件
1: 89 percent / Ambient temperature 2: NH2OH*HCl / ethanol / 0.67 h / Heating View Scheme
参考文献
Heterocycles, , vol. 15, # 1 p. 293 - 296
参考文献
Journal of the American Chemical Society, , vol. 81, p. 2472
反应条件
1.1: sodium acetate; bromine; acetic acid / 2 h / 50 - 55 °C 2.1: bromine; hydrogen bromide / acetic acid / 0.75 h / -10 °C 2.2: 2.5 h / -10 - -5 °C View Scheme
参考文献
WIGERINCK, Piet Tom Bert Paul; ANDREWS, Martin James Inglis; De WEER, Marc Maurice Germain; SABOURAULT, Nicholas Luc; KLUGE, Stefan Christian
Patent: US2011/118269 A1, 2011 ;
参考文献
Vogl; Taylor
Journal of the American Chemical Society, 1959 , vol. 81, p. 2472
