甲基 1,3-苯并二恶唑-5-羧酸酯合成路线 （共 49 条）
反应条件
1: 77 percent / chromium(VI) oxide; Celite / pyridine / 8 h / 20 °C 2: 73 percent / p-toluenesulfonic acid monohydrate; trimethyl orthoformate / 12 h / 20 °C 3: 78 percent / EtAlCl2 / CH2Cl2 / 1 h / -78 - 20 °C View Scheme
参考文献
Bulletin of the Chemical Society of Japan, , vol. 71, # 9 p. 2181 - 2185
反应条件
in methanol; benzene Ambient temperature;
参考文献
Journal of Medicinal Chemistry, , vol. 26, # 5 p. 765 - 768
反应条件
1: 2: With N-bromosuccinmide
参考文献
Organic Letters, , vol. 11, # 23 p. 5482 - 5485
参考文献
Monatshefte fuer Chemie, , vol. 90, p. 846,852, 856
参考文献
Zhang, Jianwei; Zhang, Yi; Zhang, Yanshi; Herndon, James W.
Tetrahedron, 2003 , vol. 59, # 29 p. 5609 - 5616
反应条件
1: LiAlH4 / diethyl ether / 2 h / Ambient temperature 2: 105 mg / H2 / 5percent Pd-C / methanol / 2 h / Ambient temperature 3: 1.) Pb(OAc)4 / 1.) benzene, 60 deg C, 7 h, 2.) CHCl3-MeOH, 2 d, r.t. 4: 26 mg / K2CO3 / acetone View Scheme
参考文献
Ikeya, Yukinobu; Taguchi, Heihachiro; Yoshioka, Itiro
Chemical & Pharmaceutical Bulletin, 1981 , vol. 29, # 10 p. 2893 - 2898
反应条件
lithium aluminium tetrahydride in diethyl ether 2 h; Ambient temperature;
参考文献
Ikeya, Yukinobu; Taguchi, Heihachiro; Yoshioka, Itiro
Chemical & Pharmaceutical Bulletin, 1981 , vol. 29, # 10 p. 2893 - 2898
反应条件
1: LiAlH4 / diethyl ether / 2 h / Ambient temperature 2: 105 mg / H2 / 5percent Pd-C / methanol / 2 h / Ambient temperature 3: 1.) Pb(OAc)4 / 1.) benzene, 60 deg C, 7 h, 2.) CHCl3-MeOH, 2 d, r.t. View Scheme
参考文献
Ikeya, Yukinobu; Taguchi, Heihachiro; Yoshioka, Itiro
Chemical & Pharmaceutical Bulletin, 1981 , vol. 29, # 10 p. 2893 - 2898
反应条件
potassium hydroxide in methanol T=35°C; 1 h;
参考文献
Khurana, Jitender M.; Chauhan, Sushma; Bansal, Geeti
Monatshefte fur Chemie, 2004 , vol. 135, # 1 p. 83 - 87
反应条件
sodium hydride 1) DMF, 2) 25 deg C, 12 h; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Cassels, Bruce K.; Radetski, Claudemir; Rezende, Marcos Caroli
Recueil des Travaux Chimiques des Pays-Bas, 1992 , vol. 111, # 10 p. 448 - 450
