苯并[1,3]二氧代l-5-乙酸甲酯合成路线 （共 26 条）
反应条件
1: 1.) O3/O2, 2.) Zn, CH3COOH / 1.) CH3COOH, 0 deg C, 2.) 0 deg C, 2 h 2: 75 percent / Jones reagent / acetone / 0 °C 3: 100 percent / dioxane; diethyl ether View Scheme
参考文献
Journal of Chemical Research, Miniprint, , # 7 p. 2301 - 2332
反应条件
1: 75 percent / Jones reagent / acetone / 0 °C 2: 100 percent / dioxane; diethyl ether View Scheme
参考文献
Journal of Chemical Research, Miniprint, , # 7 p. 2301 - 2332
参考文献
Chemische Berichte, , vol. 24, p. 2881
Chemische Berichte, , vol. 41, p. 2752
反应条件
bromine; acetic acid 0.5 h; Ambient temperature;
参考文献
Texas Biotechnology Corp.
Patent: US6342610 B2, 2002 ;
Location in patent: Page column 128 ;
US 6342610 B2
反应条件
tin(IV) chloride in dichloromethane T=20°C; Acylation; Friedel-Crafts acylation; 12 h;
参考文献
De Sarro, Angela; De Sarro, Giovambattista; Gitto, Rosaria; Grasso, Silvana; Micale, Nicola; Zappala, Maria
Farmaco, 1999 , vol. 54, # 3 p. 178 - 187
反应条件
phosphorous pentoxide in dichloromethane T=20°C; 16 h;
参考文献
Micale, Nicola; Ettari, Roberta; Schirmeister, Tanja; Evers, Astrid; Gelhaus, Christoph; Leippe, Matthias; Zappala, Maria; Grasso, Silvana
Bioorganic and Medicinal Chemistry, 2009 , vol. 17, # 18 p. 6505 - 6511
反应条件
1: With potassium hydroxide; water in methanol 3 h; Heating / reflux; 2: With hydrogenchloride in water pH=1;
参考文献
AUSPEX PHARMACEUTICALS, INC.
Patent: WO2008/144602 A1, 2008 ;
Location in patent: Page/Page column 64; 66 ;
WO 2008/144602 A1
反应条件
1: 97 percent / 20percent aq. KOH / methanol / 3 h / Heating 2: SOCl2 / CH2Cl2 / 3 h / Heating View Scheme
参考文献
Cabedo; Andreu; Ramirez de Arellano; Chagraoui; Serrano; Bermejo; Protais; Cortes
Journal of Medicinal Chemistry, 2001 , vol. 44, # 11 p. 1794 - 1801
反应条件
sodium hydride in N,N-dimethyl-formamide T=100°C; 0.333333 h;
参考文献
Jacobsen, Niels; Kolind-Andersen, Hans
Synthesis, 1990 , # 10 p. 911 - 914
反应条件
phosphorus pentoxide in 1,2-dichloro-ethane 28 h; Heating;
参考文献
Euro-Celtique S.A.
Patent: EP1021418 B1, 2004 ;
Location in patent: Page 11; 17 ;
