4,4,4-三氟-1-(2-呋喃基)-1,3-丁二酮合成路线 （共 10 条）
反应条件
1: With lithium hexamethyldisilazane in tetrahydrofuran T=0 - 20°C; 2: With hydrogenchloride in water; ethyl acetate
参考文献
EXELIXIS, INC.
Patent: WO2008/73825 A1, 2008 ;
Location in patent: Page/Page column 134 ;
WO 2008/073825 A1
反应条件
1: With potassium tert-butylate in benzene 2: With ethyl-α,α,α-trifluoroacetate T=5 - 20°C; 16.3333 h; 3: With sulfuric acid in water Cooling with ice;
参考文献
APATH, LLC; SLOMCZYNSKA, Urszula; OLIVO, Paul; BEATTIE, Jodi; STARKEY, Gale; NOUEIRY, Amine; ROTH, Robert
Patent: WO2010/96115 A1, 2010 ;
Location in patent: Page/Page column 55-56 ;
反应条件
1: With pyridine in chloroform T=-10 - 35°C; 2: With sulfuric acid in chloroform T=50°C; 2 h;
参考文献
Flores, Alex F.C; Brondani, Sergio; Zanatta, Nilo; Rosa, Adriano; Martins, Marcos A.P
Tetrahedron Letters, 2002 , vol. 43, # 48 p. 8701 - 8705
反应条件
pyridine in chloroform T=-10 - 35°C; Title compound not separated from byproducts;
参考文献
Tetrahedron Letters, , vol. 43, # 48 p. 8701 - 8705
反应条件
1.1: ethanol / 1 h / 0 - 20 °C 2.1: hydrogenchloride / water; tetrahydrofuran / 0.5 h / Reflux 3.1: potassium permanganate / water; acetone / 4 h / 60 °C 3.2: 20 °C View Scheme
参考文献
BAYER CROPSCIENCE AG; YONETA, Yasushi; ISHIKAWA, Koichi; SHIMOJO, Eiichi; ICHIHARA, Teruyuki; ATAKA, Masashi; SHIBUYA, Katsuhiko
Patent: WO2012/25460 A1, 2012 ;
反应条件
1: With potassium carbonate in tetrahydrofuran; water T=20°C; 0.5 h; 2: With hydrogenchloride in tetrahydrofuran; water T=0°C; pH=Ca. 2;
参考文献
Akula, Ramulu; Xiong, Yan; Ibrahim, Hasim
RSC Advances, 2013 , vol. 3, # 27 p. 10731 - 10735
反应条件
1.1: sodium nitrite; hydrogenchloride / water / 0.5 h / 0 °C 1.2: 0 °C 1.3: 85 - 90 °C 2.1: ruthenium trichloride; sodium periodate / acetonitrile; water; tetrachloromethane / 20 °C View Scheme
参考文献
AJINOMOTO CO., INC.; Matsumoto, Kayo; Sugiki, Masayuki; Yamada, Tatsuhiro; Noguchi, Misato; Takayanagi, Masaru; Takada, Atsushi; Nakagawa, Tadakiyo; Miyanaga, Wataru; Muronoi, Shin; Taniguchi, Shinya
Patent: US2013/23563 A1, 2013 ;
反应条件
1.1: NH2NH2•xH2O / ethanol / |Reflux 1.2: 0.02 h / |Reflux 2.1: sodium hydroxide; water / ethanol / 1 h / 120 °C / |Microwave irradiation; |Sealed tube View Scheme
参考文献
Ermolenko, Mikhail S.; Guillou, Sandrine; Janin, Yves L.
Tetrahedron, 2013 , vol. 69, # 1 p. 257 - 263
反应条件
1: in acetic acid
T=80°C; 18 h;
2: With sodium hydroxide in water; ethyl acetate
参考文献
EXELIXIS, INC.
Patent: WO2008/73825 A1, 2008 ;
Location in patent: Page/Page column 134 ;
WO 2008/073825 A1
反应条件
sodium acetate; acetic acid
Heating;
参考文献
Lahm, George P.; Selby, Thomas P.; Freudenberger, John H.; Stevenson, Thomas M.; Myers, Brian J.; Seburyamo, Gilles; Smith, Ben K.; Flexner, Lindsey; Clark, Christopher E.; Cordova, Daniel
Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 22 p. 4898 - 4906
