1,3,3-三甲基喹啉-2,4-二酮合成路线 （共 7 条）
反应条件
1: 3,3-dimethylquinoline-2,4(1H,3H)-dione With sodium hydride in tetrahydrofuran T=0°C; 0.333333 h; 2: methyl iodide in tetrahydrofuran T=20°C; 16 h;
参考文献
NOVARTIS AG
Patent: WO2008/76860 A1, 2008 ;
Location in patent: Page/Page column 56-57 ;
WO 2008/076860 A1
反应条件
titanium tetrachloride in dichloromethane T=20°C; 4 h; Inert atmosphere;
参考文献
Zikou, Lamprini C.; Igglessi-Markopoulou, Olga
Synthesis, 2008 , # 12 art. no. T17907SS, p. 1861 - 1866
反应条件
titanium tetrachloride in dichloromethane T=25°C; 3 h;
参考文献
Zografos, Alexandros L.; Mitsos, Christos A.; Igglessi-Markopoulou, Olga
Organic Letters, 1999 , vol. 1, # 12 p. 1953 - 1955
反应条件
1: NaH / dimethylformamide 2: 48 percent / titanium tetrachloride / CH2Cl2 / 3 h / 25 °C View Scheme
参考文献
Zografos, Alexandros L.; Mitsos, Christos A.; Igglessi-Markopoulou, Olga
Organic Letters, 1999 , vol. 1, # 12 p. 1953 - 1955
反应条件
potassium hydroxide in acetone 14 h; Heating;
参考文献
Reisch, Johannes; Mester, Iuliu
Archiv der Pharmazie (Weinheim, Germany), 1980 , vol. 313, # 9 p. 751 - 755
反应条件
potassium hydroxide in acetone 2 h; Heating; Yields of byproduct given;
参考文献
Reisch, Johannes; Mester, Iuliu
Archiv der Pharmazie (Weinheim, Germany), 1980 , vol. 313, # 9 p. 751 - 755
反应条件
potassium hydroxide in acetone 14 h; Heating;
参考文献
Reisch, Johannes; Mester, Iuliu
Archiv der Pharmazie (Weinheim, Germany), 1980 , vol. 313, # 9 p. 751 - 755
