1: N-(tert-butoxycarbonyl)-D-serine With n-butyllithium in tetrahydrofuran; hexane T=-10 - 5°C; 1 h; 2: dimethyl sulfate in tetrahydrofuran; hexane T=0 - 5°C; 9 h; 3: With sodium hydroxide; water Product distribution / selectivity; more than 3 stages;
参考文献
SCHWARZ PHARMA AG
Patent: WO2006/37574 A1, 2006 ;
Location in patent: Page/Page column 17-18 ;
1: methanol With sodium hydride in tetrahydrofuran T=0 - 20°C; 0.25 h; Cooling with iso-propanol/dry ice; 2: N-(tert-butoxycarbonyl)-D-serine in tetrahydrofuran T=20°C; 1 h; 3: methyl iodide With citric acid more than 3 stages;
参考文献
BOEHRINGER INGELHEIM INTERNATIONAL GMBH; BOEHRINGER INGELHEIM PHARMA GMBH and CO. KG
Patent: WO2005/111014 A1, 2005 ;
Location in patent: Page/Page column 132-133 ;