1-乙酰基-5-吲哚啉磺酰胺合成路线 （共 4 条）
反应条件
ammonia; triethylamine in 1,4-dioxane; dichloromethane T=20°C; 3 h; Inert atmosphere;
参考文献
BRISTOL-MYERS SQUIBB COMPANY; BORZILLERI, Robert M.; CAI, Zhen-wei; TEBBEN, Andrew J.; PEREZ, Heidi L.; ZHANG, Liping; SCHROEDER, Gretchen M.; WEI, Donna D.
Patent: WO2012/162365 A1, 2012 ;
Location in patent: Page/Page column 141-142 ;
WO 2012/162365 A1
反应条件
chlorosulfonic acid in tetrahydrofuran; dichloromethane; water; acetone
参考文献
ELI LILLY AND COMPANY
Patent: EP614887 A1, 1994 ;
反应条件
1: With hydrogenchloride; water in methanol T=20 - 80°C; 20 h; Inert atmosphere; 2: With sodium hydroxide in water pH=7 - 8;
参考文献
BRISTOL-MYERS SQUIBB COMPANY; BORZILLERI, Robert M.; CAI, Zhen-wei; TEBBEN, Andrew J.; PEREZ, Heidi L.; ZHANG, Liping; SCHROEDER, Gretchen M.; WEI, Donna D.
Patent: WO2012/162365 A1, 2012 ;
Location in patent: Page/Page column 144 ;
WO 2012/162365 A1
反应条件
1.1: hydrogenchloride; water / methanol / 20 h / 20 - 80 °C / Inert atmosphere 1.2: pH 7 - 8 2.1: 2,3-dicyano-5,6-dichloro-p-benzoquinone / 1,2-dichloro-ethane / 2 h / 75 °C / Inert atmosphere View Scheme
参考文献
BRISTOL-MYERS SQUIBB COMPANY; BORZILLERI, Robert M.; CAI, Zhen-wei; TEBBEN, Andrew J.; PEREZ, Heidi L.; ZHANG, Liping; SCHROEDER, Gretchen M.; WEI, Donna D.
Patent: WO2012/162365 A1, 2012 ;
WO 2012/162365 A1
