(S)-(-)-2-溴丙酸合成路线 （共 23 条）
反应条件
T=39°C; Geschwindigkeit der Reaktion;
参考文献
Izumiya et al.
Journal of the American Chemical Society, 1957 , vol. 79, p. 652,657 Anm. 32
参考文献
Fischer,E.
Chemische Berichte, 1907 , vol. 40, p. 491
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Fischer,E.; Warburg
Justus Liebigs Annalen der Chemie, 1905 , vol. 340, p. 171
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Abderhalden; Chang; Wurm
Hoppe-Seyler's Zeitschrift fuer Physiologische Chemie, 1911 , vol. 72, p. 35
参考文献
Fischer,E.
Chemische Berichte, 1907 , vol. 40, p. 491
Full Text Show Details
Fischer,E.; Warburg
Justus Liebigs Annalen der Chemie, 1905 , vol. 340, p. 171
反应条件
und 2 maligen Abdampfen der waessr.Loesung mit gefaelltem Bleihydroxyd;
参考文献
Fischer,E.; v. Mechel
Chemische Berichte, 1916 , vol. 49, p. 1359
反应条件
water; silver carbonate
参考文献
Fischer,E.
Chemische Berichte, 1907 , vol. 40, p. 491
反应条件
1: S-(-)-2-bromopropionic acid With sodium hydride in tetrahydrofuran 2: phenol With sodium hydride in tetrahydrofuran T=20°C; 2.5 h; Further stages.;
参考文献
Organic Letters, , vol. 4, # 20 p. 3423 - 3426
反应条件
1: 2-hydroxy-1,3-isoindolinedione With sodium hydride in N,N-dimethyl-formamide; mineral oil T=0°C; 0.166667 h; Inert atmosphere; 2: S-(-)-2-bromopropionic acid in N,N-dimethyl-formamide; mineral oil T=0 - 20°C; Inert atmosphere; 3: With hydrogenchloride in water; N,N-dimethyl-formamide; mineral oil Cooling with ice;
参考文献
Katritzky, Alan R.; Avan, Ilker; Tala, Srinivasa R.
Journal of Organic Chemistry, 2009 , vol. 74, # 22 p. 8690 - 8694
参考文献
Fischer,E.
Chemische Berichte, 1907 , vol. 40, p. 491
参考文献
Fischer,E.
Chemische Berichte, 1907 , vol. 40, p. 491
反应条件
1: 6-hydroxyhexene With sodium hydride in N,N-dimethyl-formamide T=20°C; 0.5 h; 2: S-(-)-2-bromopropionic acid in N,N-dimethyl-formamide T=0°C; 6 h; 3: With hydrogenchloride in water; N,N-dimethyl-formamide pH=1 - 2;
参考文献
PHENOMIX CORPORATION; BETANCORT, Juan Manuel; HEPPERLE, Michael E.; CAMPBELL, David Alan; WINN, David T.
Patent: WO2010/33466 A1, 2010 ;
Location in patent: Page/Page column 67 ;
WO 2010/033466 A1
