C20H29Cl2N5O2Pd; potassium carbonate in ethanol T=80°C; Sonogashira Cross-Coupling; 2 h;

1: 1-bromo-4-nitro-benzene With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine; N-ethyl-N,N-diisopropylamine in acetonitrile Sonogashira cross-coupling; 0.333333 h; Inert atmosphere; 2: anhydrous 1-octyne in acetonitrile T=50°C; Sonogashira cross-coupling; Inert atmosphere;

copper(l) iodide; sodium carbonate; cataCXium® ABn·HBr; Na2[PdCl4] in toluene T=100°C; Sonogashira coupling; 10 h;

palladium 10 on activated carbon; hydrogen in ethyl acetate P=3750.38 Torr; 3 h;