1.1: methanol / 37 °C 2.1: imidazole / acetonitrile / 4 h / 20 °C 3.1: 76.1 percent / LiH / tetrahydrofuran / 21.5 h 4.1: Pd2(dba)3(CHCl3); PPh3; 1,3-bis(1,1,1,3,3,3-hexafluoro-2-hydroxypropyl)benzene / toluene / 16 h / 40 °C 4.2: 84 percent / imidazole / dimethylformamide / 16 h / 20 °C 5.1: 94.5 percent / DIBALH / hexane / 0.5 h / -70 °C 6.1: 77.2 percent / 9-fluorenone-4-carboxylic acid / various solvent(s) / 6 h / Irradiation 7.1: triphosgene; Et3N / hexane / 1.33 h / 5 - 20 °C 8.1: 22.3 g / NaH / dimethylformamide / -45 - 0 °C View Scheme

Product distribution;

Product distribution;