(E)-3,7-二甲基-2,6-辛二烯酸乙酯合成路线 （共 17 条）
反应条件
1: diethoxyphosphoryl-acetic acid ethyl ester With n-butyllithium in tetrahydrofuran; hexane T=-60 - -20°C; Wittig reaction; 0.333333 h; 2: 6-methyl-hept-5-en-2-one in tetrahydrofuran T=-20 - 20°C; 20 h;
参考文献
Van Der Klei, Anita; De Jong, Robertus L. P.; Lugtenburg, Johan; Tielens, Aloysius G. M.
European Journal of Organic Chemistry, 2002 , # 17 p. 3015 - 3023
反应条件
sodium hydride in tetrahydrofuran T=25°C; 12 h; Yield given. Yields of byproduct given;
参考文献
Motherwell, William B.; Begis, Guillaume; Cladingboel, David E.; Jerome, Laure; Sheppard, Tom D.
Tetrahedron, 2007 , vol. 63, # 28 p. 6462 - 6476
反应条件
chloro-trimethyl-silane in dichloromethane P=7500600 Torr; 48 h; Ambient temperature; Yield given. Yields of byproduct given;
参考文献
Yamamoto, Yoshinori; Hatsuya, Satoshi; Yamada, Jun-ichi
Journal of the Chemical Society, Chemical Communications, 1988 , # 24 p. 1639 - 1640
反应条件
Candida antarctica lipase in tert-butyl alcohol T=60°C; 144 h; Enzymatic reaction;
参考文献
DR. ANDRE RIEKS - LABOR FUeR ENZYMTECHNOLOGIE GMBH
Patent: WO2005/12210 A2, 2005 ;
Location in patent: Page/Page column 44 ;
反应条件
copper(l) iodide in tetrahydrofuran; diethyl ether T=-78°C;
参考文献
Kobayashi,S.; Mukaiyama,T.
Chemistry Letters, 1974 , p. 705 - 708
反应条件
4-N,N-dimethylaminopyridine hydrochloride; dicyclohexyl-carbodiimide in dichloromethane T=23°C; 1 h;
参考文献
Masuda, Toshiya; Odaka, Yuka; Ogawa, Natsuko; Nakamoto, Katsuo; Kuninaga, Hideki
Journal of Agricultural and Food Chemistry, 2008 , vol. 56, # 2 p. 597 - 601
反应条件
1: NaOMe / methanol 2: KOtBu / tetrahydrofuran 3: Na-Hg / ethanol View Scheme
参考文献
Julia,M.; Arnould,D.
Bulletin de la Societe Chimique de France, 1973 , p. 743 - 746
反应条件
1: KOtBu / tetrahydrofuran 2: Na-Hg / ethanol View Scheme
参考文献
Kobayashi,S.; Mukaiyama,T.
Chemistry Letters, 1974 , p. 705 - 708
反应条件
1: (i) nBuLi, THF, (ii) /BRN= 385653/ 2: ethanol / 4 h / Ambient temperature 3: CuI / tetrahydrofuran; diethyl ether / -78 °C View Scheme
参考文献
Kobayashi,S.; Mukaiyama,T.
Chemistry Letters, 1974 , p. 705 - 708
反应条件
1: ethanol / 4 h / Ambient temperature 2: CuI / tetrahydrofuran; diethyl ether / -78 °C View Scheme
参考文献
Kobayashi,S.; Mukaiyama,T.
Chemistry Letters, 1974 , p. 705 - 708
