2-(4-溴苯基)-4,4-二甲基-4,5-二氢噁唑合成路线 （共 8 条）
反应条件
thionyl chloride in dichloromethane; toluene T=20°C; 72 h;
参考文献
Houlihan, William J.; Boja, John W.; Kopajtic, Theresa A.; Kuhar, Michael J.; Degrado, Sylvia J.; Toledo, Leonel
Medicinal Chemistry Research, 1998 , vol. 8, # 1-2 p. 77 - 90
反应条件
1: 4-bromophenylacetic acid With pyridine; 2,4,6-trichloro-1,3,5-triazine in dichloromethane T=0°C; 0.25 h; 2: 2-amino-2-methyl-propan-1-ol With indium in dichloromethane T=20°C; 20 h;
参考文献
Kangani, Cyrous O.; Day, Billy W.
Tetrahedron Letters, 2009 , vol. 50, # 38 p. 5332 - 5335
反应条件
thionyl chloride; triethylamine in dichloromethane; toluene
参考文献
Otsuka Pharmaceutical Company, Limited
Patent: US6096735 A1, 2000 ;
反应条件
1: With triethylamine in dichloromethane T=0 - 20°C; 5 h; 2: With thionyl chloride in dichloromethane T=0 - 20°C; 3 h;
参考文献
Otsuka Pharmaceuticals Co., Ltd.
Patent: US6335327 B1, 2002 ;
Location in patent: Page column 84 ;
反应条件
zinc(II) chloride 15 h; Irradiation;
参考文献
Clarke, David S.; Wood, Robin
Synthetic Communications, 1996 , vol. 26, # 7 p. 1335 - 1340
反应条件
1: 82 percent / CH2Cl2 / 24 h / 20 °C 2: 60 percent / thionyl chloride / toluene; CH2Cl2 / 72 h / 20 °C View Scheme
参考文献
Houlihan, William J.; Boja, John W.; Kopajtic, Theresa A.; Kuhar, Michael J.; Degrado, Sylvia J.; Toledo, Leonel
Medicinal Chemistry Research, 1998 , vol. 8, # 1-2 p. 77 - 90
反应条件
(i) Mg, BrCH2CH2Br, THF, (ii) /BRN= 605308/, (iii) /BRN= 1718733/, H2SO4; Multistep reaction;
参考文献
Meyers,A.I. et al.
Journal of Organic Chemistry, 1974 , vol. 39, p. 2787 - 2793
反应条件
1: 1.) Mg, I2 / 1.) THF, reflux, 5.5 h, 2.) THF, 4 deg C to room temperature, overnight; reflux, 1 h
2: acetonitrile / 48 h / 120 °C
3: aq. NaOH / 24 h / Ambient temperature
View Scheme
参考文献
Taylor, Edward C.; Chaudhuri, Rajendra P.; Watson, Samuel E.
Tetrahedron, 1999 , vol. 55, # 6 p. 1631 - 1638
