2-氨基-2-氰基乙酸乙酯合成路线 （共 37 条）
反应条件
hydrogen; platinum(IV) oxide in ethanol P=3000.3 Torr;
参考文献
ASTRAZENECA AB
Patent: WO2007/73296 A1, 2007 ;
Location in patent: Page/Page column 38 ;
WO 2007/073296 A1
反应条件
sodium dithionite; sodium hydrogencarbonate in water T=42°C; 0.5 h;
参考文献
PFIZER PRODUCTS INC.
Patent: WO2008/59368 A2, 2008 ;
Location in patent: Page/Page column 66-67 ;
反应条件
sodium dithionite; sodium hydrogencarbonate in water T=20°C; 2.08333 h;
参考文献
Buettelmann, Bernd; Ceccarelli, Simona Maria; Jaeschke, Georg; Kolczewski, Sabine; Porter, Richard Hugh Philip; Vieira, Eric
Patent: US2006/160857 A1, 2006 ;
Location in patent: Page/Page column 37 ;
US 20060160857 A1
反应条件
1: hydrogenchloride; sodium nitrite 2: acetic acid; zinc View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 22, # 1 p. 553 - 557
反应条件
potassium chloride; N-hexadecyl-N,N,N-trimethylammonium bromide in methanol T=30°C; polarographic reduction at pH=6.0 (Britton-Robinson buffer); Mechanism;
参考文献
Journal of the Indian Chemical Society, , vol. 59, # 2 p. 191 - 194
反应条件
1: 2.) HCl, sodium ethylate / 1.) acetonitrile, 90 deg C, 1 h; 2.) ethanol, 20 deg C, 5 h 2: 98 percent / 50percent H3PO4, NaNO2 / H2O / 1 h / 0 °C View Scheme
参考文献
J. Gen. Chem. USSR (Engl. Transl.), , vol. 57, # 3 p. 692 - 701,609 - 617
反应条件
1: acetonitrile / 0.75 h / Heating 2: 1.7 g / H2S (gas) / pyridine / 48 h View Scheme
参考文献
Sen, A. K.; Mukhopadhyay, Ajoy Kumar
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1981 , vol. 20, # 4 p. 275 - 278
反应条件
4-(N,N-dimethlyamino)pyridine in dichloromethane T=20°C; 1 h;
参考文献
Breistein, Palle; Johansson, Jonas; Ibrahem, Ismail; Lin, Shuangzheng; Deiana, Luca; Sun, Junliang; Cordova, Armando
Advanced Synthesis and Catalysis, 2012 , vol. 354, # 6 p. 1156 - 1162
反应条件
pyridine in dichloromethane 0 deg C up to RT;
参考文献
Caille; Didierlaurent; Lefrancois; Lelievre; Sury; Aszodi
Synthesis, 1995 , # 6 p. 635 - 637
参考文献
Lu, Xiaoyun; Liu, Xiaobo; Wan, Baojie; Franzblau, Scott G.; Chen, Lili; Zhou, Changlin; You, Qidong
European Journal of Medicinal Chemistry, 2012 , vol. 49, p. 164 - 171
