2-氨基-2-氰基乙酸乙酯合成路线 （共 37 条）
反应条件
in diethyl ether; ethanol T=-20°C; overnight; Yield given;
参考文献
Meester, Johan W. G. De; Plas, Henk C. van der; Middelhoven, Wouter J.
Journal of Heterocyclic Chemistry, 1987 , vol. 24, p. 441 - 451
反应条件
ammonia in methanol T=0 - 5°C; 1 h;
参考文献
IND-SWIFT LABORATORIES LIMITED; BHIRUD, Shekhar Bhaskar; SARIN, Gurdeep Singh; GUPTA, Neeraj; TIWARI, Parveen Kumar; CHIDAMBARAM, Venkateswaran Srinivasan; WADHWA, Lalit
Patent: WO2010/140168 A1, 2010 ;
Location in patent: Page/Page column 14 ;
反应条件
1: orthoformic acid triethyl ester; 2-amino-2-cyanoacetic acid ethyl ester in acetonitrile 0.833333 h; Heating; 2: benzylamine in acetonitrile T=20°C; 16 h; Further stages.;
参考文献
Lin, Xiaoyu; Robins, Morris J.
Collection of Czechoslovak Chemical Communications, 2006 , vol. 71, # 7 p. 1029 - 1041
反应条件
1: acetonitrile / 0.75 h / Reflux 2: acetonitrile View Scheme
参考文献
Costanzi, Stefano; Rouse, Sean P.N.; Vanbaelinghem, Laurence; Prior, Timothy J.; Ewing, David F.; Boa, Andrew N.; MacKenzie, Grahame
Tetrahedron Letters, 2012 , vol. 53, # 4 p. 412 - 415
反应条件
1: 2-amino-2-cyanoacetic acid ethyl ester; methyl 5-norbornene-2-carboximidate hydrochloride in chloroform 1.5 h; Heating; 2: benzylamine in chloroform 21 h; Heating;
参考文献
Herr, R. Jason; Vogt, Paul F.; Meckler, Harold; Trova, Michael P.; Schow, Steven R.; Petter, Russell C.
Journal of Organic Chemistry, 2002 , vol. 67, # 1 p. 188 - 193
反应条件
in chloroform 1.5 h; Heating;
参考文献
Herr, R. Jason; Vogt, Paul F.; Meckler, Harold; Trova, Michael P.; Schow, Steven R.; Petter, Russell C.
Journal of Organic Chemistry, 2002 , vol. 67, # 1 p. 188 - 193
反应条件
1: TEA / CH2Cl2 / 20 °C 2: HCl(g) / dioxane / 20 °C View Scheme
参考文献
Wang, Xiaojing; Ebens, JR., Allen J.
Patent: US2011/59961 A1, 2011 ;
US 20110059961 A1
参考文献
Cook et al.
Journal of the Chemical Society, 1949 , p. 1074,1076
参考文献
Cook et al.
Journal of the Chemical Society, 1949 , p. 1074,1076
反应条件
1: sodium hydrogencarbonate / dichloromethane; water / 0.5 h / 20 °C 2: Lawesson's reagent / pyridine / 15 h / Reflux View Scheme
参考文献
GENENTECH, INC.; Hodges, Alastair James; Matteucci, Mizio; Sharpe, Andrew; Sun, Minghua; Wang, Xiaojing; Tsui, Vickie H.
Patent: US2013/79321 A1, 2013 ;
