2-氨基-2-氰基乙酸乙酯合成路线 （共 37 条）
参考文献
Cook et al.
Journal of the Chemical Society, 1948 , p. 2031
参考文献
Dainippon Pharmaceutical Co., Ltd.
Patent: US5258382 A1, 1993 ;
参考文献
Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai
Patent: US5831072 A1, 1998 ;
US 5831072 A
反应条件
hydrogenchloride; sodium ethanolate
1.) acetonitrile, 90 deg C, 1 h; 2.) ethanol, 20 deg C, 5 h; Yield given. Multistep reaction;
参考文献
NEUROGEN CORPORATION
Patent: WO2009/121036 A2, 2009 ;
Location in patent: Page/Page column 41 ;
WO 2009/121036 A2
反应条件
1: orthoformic acid triethyl ester; 2-amino-2-cyanoacetic acid ethyl ester in acetonitrile
T=90°C; 1.16667 h;
2: methylamine in ethanol; acetonitrile
T=20°C; 20 h;
参考文献
NEUROGEN CORPORATION
Patent: WO2008/24433 A2, 2008 ;
Location in patent: Page/Page column 44-45 ;
反应条件
1: diethyl ether
2: water; Na2CO3
3: Raney nickel; ethanol
View Scheme
参考文献
Cook et al.
Journal of the Chemical Society, 1948 , p. 2031
反应条件
in acetonitrile
0.75 h; Heating / reflux;
参考文献
IRM LLC
Patent: WO2006/47516 A2, 2006 ;
Location in patent: Page/Page column 65-66; 67 ;
WO 2006/047516 A2
