4-氯-3-三氟甲基异氰酸苯酯合成路线

参考文献

Bioorganic and Medicinal Chemistry, , vol. 21, # 11 p. 2960 - 2967

75-44-5光气+

320-51-42-氯-5-氨基三氟甲苯

327-78-64-氯-3-三氟甲基异氰酸苯酯

参考文献

Justus Liebigs Annalen der Chemie, , vol. 562, p. 75,1114

320-51-42-氯-5-氨基三氟甲苯+

503-38-8氯甲酸三氯甲酯

327-78-64-氯-3-三氟甲基异氰酸苯酯

参考文献

US2012/53192 A1, ;

Page/Page column 4 ;

327-78-64-氯-3-三氟甲基异氰酸苯酯+

320-51-42-氯-5-氨基三氟甲苯

370-50-31,3-二[4-氯-3-(三氟甲基)苯基]脲

参考文献

Denoyelle, Severine; Chen, Ting; Chen, Limo; Wang, Yibo; Klosi, Edvin; Halperin, Jose A.; Aktas, Bertal H.; Chorev, Michael
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 1 p. 402 - 409

327-78-64-氯-3-三氟甲基异氰酸苯酯

370-50-31,3-二[4-氯-3-(三氟甲基)苯基]脲

参考文献

Dumas, Jacques; Miller, Scott; Osterhout, Martin; Khire, Uday; Lowinger, Timothy B.; Riedl, Bernd; Scott, William J.; Smith, Roger A.; Wood, Jill E.; Gunn, David; Rodriguez, Martha; Wang, Ming; Turner, Tiffany; Brennan, Catherine
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Location in patent: Page/Page column 23 ;
US 20080269265 A1

284462-37-94-(4-氨基苯氧基)-N-甲基-2-吡啶甲酰胺

99586-65-94-氯吡啶-2-甲酰胺

参考文献

Riedl, Bernd; Dumas, Jacques; Khire, Uday; Lowinger, Timothy B.; Scott, William J.; Smith, Roger A.; Wood, Jill E.; Monahan, Mary-Katherine; Natero, Reina; Renick, Joel; Sibley, Robert N.
Patent: US2001/11135 A1, 2001 ;
US 20010011135 A1
Title/Abstract Full Text Show Details
BAYER CORPORATION
Patent: US2002/165394 A1, 2002 ;
US 20020165394 A1
Title/Abstract Full Text Show Details
BAYER CORPORATION
Patent: US2003/181442 A1, 2003 ;

99586-65-94-氯吡啶-2-甲酰胺

参考文献

Riedl, Bernd; Dumas, Jacques; Khire, Uday; Lowinger, Timothy B.; Scott, William J.; Smith, Roger A.; Wood, Jill E.; Monahan, Mary-Katherine; Natero, Reina; Renick, Joel; Sibley, Robert N.
Patent: US2001/11135 A1, 2001 ;
US 20010011135 A1
Title/Abstract Full Text Show Details
BAYER CORPORATION
Patent: US2002/165394 A1, 2002 ;
US 20020165394 A1
Title/Abstract Full Text Show Details
BAYER CORPORATION
Patent: US2003/181442 A1, 2003 ;

284462-86-8+

327-78-64-氯-3-三氟甲基异氰酸苯酯+

350-46-9对氟硝基苯+

99-93-4对羟基苯乙酮

75919-92-54-乙酰-4-硝基联苯醚

参考文献

Riedl, Bernd; Dumas, Jacques; Khire, Uday; Lowinger, Timothy B.; Scott, William J.; Smith, Roger A.; Wood, Jill E.; Monahan, Mary-Katherine; Natero, Reina; Renick, Joel; Sibley, Robert N.
Patent: US2001/11135 A1, 2001 ;
US 20010011135 A1
Title/Abstract Full Text Show Details
BAYER CORPORATION
Patent: US2002/165394 A1, 2002 ;
US 20020165394 A1
Title/Abstract Full Text Show Details
BAYER CORPORATION
Patent: US2003/181442 A1, 2003 ;

757251-39-14-(4-氨基-3-氟苯氧基)-N-甲基吡啶-2-甲酰胺+

327-78-64-氯-3-三氟甲基异氰酸苯酯

755037-03-7瑞格菲尼

参考文献

WO2005/9961 A2, ;

Page/Page column 47 ;
WO 2005/009961 A2

284462-37-94-(4-氨基苯氧基)-N-甲基-2-吡啶甲酰胺+

327-78-64-氯-3-三氟甲基异氰酸苯酯

284461-73-0索拉非尼

参考文献

Riedl, Bernd; Dumas, Jacques; Khire, Uday; Lowinger, Timothy B.; Scott, William J.; Smith, Roger A.; Wood, Jill E.; Monahan, Mary-Katherine; Natero, Reina; Renick, Joel; Sibley, Robert N.
Patent: US2001/11135 A1, 2001 ;
US 20010011135 A1