4-氯-3-三氟甲基异氰酸苯酯合成路线 （共 22 条）
反应条件
in dichloromethane; dimethyl sulfoxide T=20°C; 0.333333 h; Inert atmosphere;
参考文献
EP2548867 A1, ;
Paragraph 0081; 0082 ;
反应条件
1.1: dichloromethane / 16 h / 20 °C 2.1: potassium tert-butylate / N,N-dimethyl-formamide / 3 h 2.2: 1.5 h / 80 °C View Scheme
参考文献
BAYER CORPORATION
Patent: US2002/165394 A1, 2002 ;
US 20020165394 A1
反应条件
in dichloromethane T=20°C;
参考文献
Brunton, Shirley A.; Stibbard, John H. A.; Rubin, Lee L.; Kruse, Lawrence I.; Guicherit, Oivin M.; Boyd, Edward A.; Price, Steven
Journal of Medicinal Chemistry, 2008 , vol. 51, # 5 p. 1108 - 1110
参考文献
Geigy A. G.
Patent: US2745874 , 1954 ;
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Geigy A. G.
Patent: DE1003717 , 1954 ;
反应条件
hydrogenchloride in hexane; dichloromethane; acetone
参考文献
Hoffmann-La Roche Inc.
Patent: US4234736 A1, 1980 ;
反应条件
1: Na2CO3 / tetrahydrofuran / Heating
2: HCl (6N) / acetone / Heating
View Scheme
参考文献
Link; Stohler
European Journal of Medicinal Chemistry, 1984 , vol. 19, # 3 p. 261 - 265
反应条件
in hexane
Ambient temperature;
参考文献
DeVries, Vern G.; Bloom, Jonathan D.; Dutia, Minu D.; Katocs, Andrew S.; Largis, Elwood E.
Journal of Medicinal Chemistry, 1989 , vol. 32, # 10 p. 2318 - 2325
反应条件
in hexane
Ambient temperature;
参考文献
DeVries, Vern G.; Bloom, Jonathan D.; Dutia, Minu D.; Katocs, Andrew S.; Largis, Elwood E.
Journal of Medicinal Chemistry, 1989 , vol. 32, # 10 p. 2318 - 2325
参考文献
Riedl, Bernd; Dumas, Jacques; Khire, Uday; Lowinger, Timothy B.; Scott, William J.; Smith, Roger A.; Wood, Jill E.; Monahan, Mary-Katherine; Natero, Reina; Renick, Joel; Sibley, Robert N.
Patent: US2001/11135 A1, 2001 ;
US 20010011135 A1
