6-羟基-3,4-二氢-2H-喹啉-1-羧酸叔丁酯合成路线 （共 3 条）
反应条件
sodium hydroxide in 1,4-dioxane; water T=20°C;
参考文献
ELI LILLY AND COMPANY
Patent: WO2004/26837 A2, 2004 ;
Location in patent: Page 17-18 ;
WO 2004/026837 A2
反应条件
1: 100 percent / H2 / PtO2 / methanol / 12 h / 3102.89 Torr 2: BBr3 / CH2Cl2 / 4 h / -78 °C 3: NaOH / dioxane View Scheme
参考文献
Jesudason, Cynthia D.; Beavers, Lisa S.; Cramer, Jeffrey W.; Dill, Joelle; Finley, Don R.; Lindsley, Craig W.; Stevens, F. Craig; Gadski, Robert A.; Oldham, Samuel W.; Pickard, R. Todd; Siedem, Christopher S.; Sindelar, Dana K.; Singh, Ajay; Watson, Brian M.; Hipskind, Philip A.
Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 13 p. 3415 - 3418
反应条件
1: BBr3 / CH2Cl2 / 4 h / -78 °C 2: NaOH / dioxane View Scheme
参考文献
Jesudason, Cynthia D.; Beavers, Lisa S.; Cramer, Jeffrey W.; Dill, Joelle; Finley, Don R.; Lindsley, Craig W.; Stevens, F. Craig; Gadski, Robert A.; Oldham, Samuel W.; Pickard, R. Todd; Siedem, Christopher S.; Sindelar, Dana K.; Singh, Ajay; Watson, Brian M.; Hipskind, Philip A.
Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 13 p. 3415 - 3418
