2-氰基-5-氟吡啶合成路线

参考文献

ASTRAZENECA AB; NPS PHARMACEUTICALS, INC.
Patent: WO2005/66155 A1, 2005 ;
Location in patent: Page/Page column 23 ;
WO 2005/066155 A1

557-21-1氰化锌+

41404-58-42-溴-5-氟吡啶

327056-62-22-氰基-5-氟吡啶

参考文献

ASTRAZENECA AB; ASTRAZENECA UK LIMITED; ALMEIDA, Lynsie; CHUAQUI, Claudio, Edmundo; GUAN, Amy; IOANNIDIS, Stephanos; LAMB, Michelle; PENG, Bo; SU, Qibin
Patent: WO2010/20810 A1, 2010 ;
Location in patent: Page/Page column 63-64 ;
WO 2010/020810 A1

41404-58-42-溴-5-氟吡啶+

557-21-1氰化锌

327056-62-22-氰基-5-氟吡啶

参考文献

ASTRAZENECA AB; ASTRAZENECA UK LIMITED
Patent: WO2008/129255 A1, 2008 ;
Location in patent: Page/Page column 65-66 ;
WO 2008/129255 A1

89809-64-35-氯-2-氰基吡啶

327056-62-22-氰基-5-氟吡啶

参考文献

ELI LILLY AND COMPANY
Patent: WO2005/66126 A1, 2005 ;
Location in patent: Page/Page column 75-76 ;
WO 2005/066126 A1

97483-77-75-溴-2-氰基吡啶

327056-62-22-氰基-5-氟吡啶

参考文献

WO2006/12374 A1, ;

Page/Page column 214 ;
WO 2006/012374 A1

41404-58-42-溴-5-氟吡啶+

75-86-5丙酮氰醇

327056-62-22-氰基-5-氟吡啶

参考文献

WO2008/54284 A1, ;

Page/Page column 4 ;

41404-58-42-溴-5-氟吡啶+

143-33-9氰化钠+

544-92-3氰化亚铜

327056-62-22-氰基-5-氟吡啶

参考文献

ADDEX PHARMA S.A.
Patent: WO2008/56259 A2, 2008 ;
Location in patent: Page/Page column 25 ;
WO 2008/056259 A2

41404-58-42-溴-5-氟吡啶+

544-92-3氰化亚铜+

151-50-8氰化钾

327056-62-22-氰基-5-氟吡啶

参考文献

ASTRAZENECA AB; ASTRAZENECA UK LIMITED
Patent: WO2006/123113 A2, 2006 ;
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WO 2006/123113 A2

21717-96-42-氨基-5-氟吡啶

327056-62-22-氰基-5-氟吡啶

参考文献

Bioorganic and Medicinal Chemistry Letters, , vol. 17, # 19 p. 5349 - 5352

41404-58-42-溴-5-氟吡啶+

544-92-3氰化亚铜

327056-62-22-氰基-5-氟吡啶

参考文献

Bioorganic and Medicinal Chemistry Letters, , vol. 17, # 19 p. 5349 - 5352