(2E)-N-(4-溴苯基)-3-乙氧基-2-丙烯酰胺合成路线 （共 10 条）
反应条件
pyridine in dichloromethane T=25°C; 1.5 h;
参考文献
European Journal of Medicinal Chemistry, , vol. 35, # 10 p. 931 - 940
反应条件
1: (EtO)2CHCH2CO2H With thionyl chloride T=80°C; 1 h; 2: 4-bromo-aniline With pyridine in dichloromethane T=20°C;
参考文献
Journal of Medicinal Chemistry, , vol. 48, # 1 p. 306 - 311
反应条件
1.1: 85 percent / aq. NaOH / 0.5 h / 110 °C 2.1: SOCl2 / 1 h / 80 °C 2.2: pyridine / CH2Cl2 / 20 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 48, # 1 p. 306 - 311
反应条件
1: 83 percent / conc. H2SO4 / 3 h / 25 °C 2: 83 percent / POCl3 / 1 h / Heating 3: 77 percent / NaOMe / 17 h / Heating View Scheme
参考文献
Kim, Younghee; Son, Jiwon; Kim, Juhyeon; Baek, Du-Jong; Lee, Yong Sup; Lim, Eun Jeong; Lee, Jae Kyun; Pae, Ae Nim; Min, Sun-Joon; Cho, Yong Seo
Chemical and Pharmaceutical Bulletin, 2014 , vol. 62, # 6 p. 508 - 518
反应条件
sulfuric acid T=100°C;
参考文献
SMITHKLINE BEECHAM CORPORATION
Patent: WO2006/132739 A2, 2006 ;
Location in patent: Page/Page column 35-36 ;
参考文献
Boehringer Ingelheim Pharma GmbH and Co. KG
Patent: US2004/209865 A1, 2004 ;
US 20040209865 A1
反应条件
1: 83 percent / conc. H2SO4 / 3 h / 25 °C 2: 83 percent / POCl3 / 1 h / Heating View Scheme
参考文献
Kim, Younghee; Son, Jiwon; Kim, Juhyeon; Baek, Du-Jong; Lee, Yong Sup; Lim, Eun Jeong; Lee, Jae Kyun; Pae, Ae Nim; Min, Sun-Joon; Cho, Yong Seo
Chemical and Pharmaceutical Bulletin, 2014 , vol. 62, # 6 p. 508 - 518
反应条件
1: sulfuric acid / 1.5 h / 20 °C 2: 50 percent / K2CO3; CuI / dimethylformamide / 22 h / 160 °C View Scheme
参考文献
Zaragoza, Florencio; Stephensen, Henrik; Peschke, Bernd; Rimvall, Karin
Journal of Medicinal Chemistry, 2005 , vol. 48, # 1 p. 306 - 311
反应条件
1.1: sulfuric acid / 1.5 h / 20 °C
2.1: 1-methyl-pyrrolidin-2-one / 7 h / 202 °C
2.2: 91 percent / FeCl3*6H2O; aq. HCl / 72 h / 20 °C
3.1: 80 percent / POCl3 / 2 h / 110 °C
View Scheme
参考文献
Zaragoza, Florencio; Stephensen, Henrik; Peschke, Bernd; Rimvall, Karin
Journal of Medicinal Chemistry, 2005 , vol. 48, # 1 p. 306 - 311
反应条件
1.1: sulfuric acid / 1.5 h / 20 °C
2.1: 1-methyl-pyrrolidin-2-one / 7 h / 202 °C
2.2: 91 percent / FeCl3*6H2O; aq. HCl / 72 h / 20 °C
View Scheme
参考文献
Zaragoza, Florencio; Stephensen, Henrik; Peschke, Bernd; Rimvall, Karin
Journal of Medicinal Chemistry, 2005 , vol. 48, # 1 p. 306 - 311
