反应条件
1: (3,5-dimethyl-1-phenyl-1H-pyrazol-4-yl)-acetic acid ethyl ester With water; lithium hydroxide hydrate in tetrahydrofuran
T=50°C; 2 h;
2: benzylamine With n-ethyl morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride in dichloromethane; N,N-dimethyl-formamide
T=20°C; 16 h;
参考文献
Chambers, Laura J.; Stevens, Alexander J.; Moses, Andrew P.; Michel, Anton D.; Walter, Daryl S.; Davies, David J.; Livermore, David G.; Fonfria, Elena; Demont, Emmanuel H.; Vimal, Mythily; Theobald, Pam J.; Beswick, Paul J.; Gleave, Robert J.; Roman, Shilina A.; Senger, Stefan
Bioorganic and Medicinal Chemistry Letters, 2010 , vol. 20, # 10 p. 3161 - 3164
