(3,5-二甲基-1-苯基-1H-吡唑-4-基)乙酸合成路线 （共 12 条）
反应条件
sodium hydroxide in ethanol; water
参考文献
Byk Gulden Lomberg Chemische Fabrik GmbH
Patent: US4146721 A1, 1979 ;
反应条件
water; potassium hydroxide T=100°C; 18 h;
参考文献
Attaryan, O. S.; Sahakyan, A. A.; Akopyan, A. E.; Sahakyan, L. A.; Asratyan, G. V.
Russian Journal of General Chemistry, 2012 , vol. 82, # 9 p. 1610 - 1612,3
Zhurnal Obshchei Khimii, 2012 , vol. 82, # 9 p. 1575 - 1577
反应条件
1.1: sodium hydride / tetrahydrofuran / 0 °C 1.2: 20 °C 2.1: acetic acid / 20 °C 3.1: trifluoroacetic acid / chloroform / 20 °C View Scheme
参考文献
Andres, Miriam; Bravo, Monica; Buil, Maria Antonia; Calbet, Marta; Castro, Jordi; Domenech, Teresa; Eichhorn, Peter; Ferrer, Manel; Gomez, Elena; Lehner, Martin D.; Moreno, Imma; Roberts, Richard S.; Sevilla, Sara
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 11 p. 3349 - 3353
反应条件
1: acetic acid / 20 °C 2: trifluoroacetic acid / chloroform / 20 °C View Scheme
参考文献
Andres, Miriam; Bravo, Monica; Buil, Maria Antonia; Calbet, Marta; Castro, Jordi; Domenech, Teresa; Eichhorn, Peter; Ferrer, Manel; Gomez, Elena; Lehner, Martin D.; Moreno, Imma; Roberts, Richard S.; Sevilla, Sara
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 11 p. 3349 - 3353
反应条件
1: water / dimethyl sulfoxide / 1 h / 60 °C 2: water; potassium hydroxide / 18 h / 100 °C View Scheme
参考文献
Attaryan, O. S.; Sahakyan, A. A.; Akopyan, A. E.; Sahakyan, L. A.; Asratyan, G. V.
Russian Journal of General Chemistry, 2012 , vol. 82, # 9 p. 1610 - 1612,3
Zhurnal Obshchei Khimii, 2012 , vol. 82, # 9 p. 1575 - 1577
反应条件
1: copper diacetate; oxygen; pyridine / dichloromethane / 20 °C 2: trifluoroacetic acid / chloroform / 20 °C View Scheme
参考文献
Andres, Miriam; Bravo, Monica; Buil, Maria Antonia; Calbet, Marta; Castro, Jordi; Domenech, Teresa; Eichhorn, Peter; Ferrer, Manel; Gomez, Elena; Lehner, Martin D.; Moreno, Imma; Roberts, Richard S.; Sevilla, Sara
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 11 p. 3349 - 3353
反应条件
1: SOCl2 / 1,2-dichloro-ethane / 1 h / Heating 2: 29 percent / 1,2-dichloro-ethane / Ambient temperature View Scheme
参考文献
Zagorevskii, V. A.; Vlasova, N. V.; Zykov, D. A.; Kirsanova, Z. D.
Pharmaceutical Chemistry Journal, 1989 , vol. 23, # 8 p. 684 - 689
Khimiko-Farmatsevticheskii Zhurnal, 1989 , vol. 23, # 8 p. 966 - 971
反应条件
1: SOCl2 / 1,2-dichloro-ethane / 1 h / Heating 2: 57.3 percent / 1,2-dichloro-ethane / Ambient temperature View Scheme
参考文献
Zagorevskii, V. A.; Vlasova, N. V.; Zykov, D. A.; Kirsanova, Z. D.
Pharmaceutical Chemistry Journal, 1989 , vol. 23, # 8 p. 684 - 689
Khimiko-Farmatsevticheskii Zhurnal, 1989 , vol. 23, # 8 p. 966 - 971
反应条件
1: SOCl2 / 1,2-dichloro-ethane / 1 h / Heating 2: 61.7 percent / 1,2-dichloro-ethane / Ambient temperature View Scheme
参考文献
Zagorevskii, V. A.; Vlasova, N. V.; Zykov, D. A.; Kirsanova, Z. D.
Pharmaceutical Chemistry Journal, 1989 , vol. 23, # 8 p. 684 - 689
Khimiko-Farmatsevticheskii Zhurnal, 1989 , vol. 23, # 8 p. 966 - 971
反应条件
1: SOCl2 / 1,2-dichloro-ethane / 1 h / Heating 2: 35.1 percent / 1,2-dichloro-ethane / Ambient temperature View Scheme
参考文献
Pharmaceutical Chemistry Journal, , vol. 23, # 8 p. 684 - 689
Khimiko-Farmatsevticheskii Zhurnal, , vol. 23, # 8 p. 966 - 971
