1: 1,3-Dibromo-2-(3-bromo-propoxy)-benzene With n-butyllithium in tetrahydrofuran; hexane; toluene T=-78 - 5°C; 4.5 h; 2: N,N-dimethyl-formamide in tetrahydrofuran; hexane; toluene T=5 - 20°C; 0.666667 h; 3: With hydrogenchloride; water in tetrahydrofuran; hexane; toluene T=20°C;

n-butyllithium in tetrahydrofuran; N-methyl-acetamide

1: (2,6-dibromophenyl) (2-chloropropyl) ether With n-butyllithium in tetrahydrofuran; hexane T=-40°C; Parham cyclisation; 1 h; 2: N,N-dimethyl-formamide in tetrahydrofuran T=-40 - 20°C; Further stages.;

1.1: 49 percent / K2CO3; Bu4NHSO4 / acetonitrile / 20 h / 45 °C 2.1: n-BuLi / tetrahydrofuran; hexane / 1 h / -40 °C 2.2: 76 percent / tetrahydrofuran / -40 - 20 °C View Scheme