4-羟基-3-硝基苯甲腈合成路线 （共 24 条）
反应条件
sodium thiosulfate in ethanol; water
参考文献
Abbott Laboratories
Patent: US2002/156081 A1, 2002 ;
US 20020156081 A1
反应条件
1: 84 percent / SnCl2; 37 percent HCl / 3 h / 20 °C 2: sodium carbonate / CHCl3 / 3 h / 20 °C 3: K2CO3 / dimethylformamide / 3 h / 80 °C View Scheme
参考文献
Caliendo, Giuseppe; Grieco, Paolo; Perissutti, Elisa; Santagada, Vincenzo; Santini, Antonello; Albrizio, Stefania; Fattorusso, Caterina; Pinto, Aldo; Sorrentino, Raffaella
European Journal of Medicinal Chemistry, 1998 , vol. 33, # 12 p. 957 - 967
反应条件
KIO3; sodium hydroxide; sulfuric acid; potassium iodide in ethanol; water 1 h, reflux; overnight at room temp.;
参考文献
Markus; Kwon
Journal of Pharmaceutical Sciences, 1994 , vol. 83, # 12 p. 1729 - 1734
反应条件
potassium carbonate in N,N-dimethyl-formamide
T=10 - 35°C; 2 h;
参考文献
Takeda Pharmaceutical Company Limited
Patent: EP1541576 A1, 2005 ;
Location in patent: Page/Page column 43 ;
EP 1541576 A1
