N-bromosuccinmide in dichloromethane T=20°C; 4.5 h; DarknessMolecular sieve;

bromine 0.25 h; Phase-vanishing reaction with phase screenNeat (no solvent);

water; sodium acetate in acetonitrile T=20°C; 5 h;

triphenylphosphine; zinc dibromide; diethylazodicarboxylate in tetrahydrofuran 0.5 h; Ambient temperature;

1.1: HCl / H2O; various solvent(s) / 12 h / 20 °C 1.2: NaHCO3 / various solvent(s) / 0.5 h / 20 °C 1.3: 96 percent / NaOH / tetrahydrofuran; H2O; various solvent(s) / 4 h / 20 °C 2.1: EDCI / CH2Cl2 / 2 h / 20 °C 3.1: Novozyme-435; Et3N / various solvent(s) / 4 h / 20 °C / Enzymatic reaction 4.1: N,N'-dibromodimethylhydantoin / acetonitrile; H2O / 3 h / 20 °C View Scheme

1: methyllithium With copper(l) iodide in diethyl ether T=0°C; 0.25 h; Inert atmosphere; 2: 5-bromo-4-pentanolide in diethyl ether T=-70 - 0°C; 5.5 h; Inert atmosphere; 3: With ammonium chloride in diethyl ether; water

in methanol T=20°C; 0.333333 h; Inert atmosphere;

bei 20-stuendigem Sieden;