(2S,3r)-2-((s)-1-(3,5-双(三氟甲基)苯基)乙氧基)-3-(4-氟苯基)吗啉合成路线 （共 6 条）
反应条件
hydrogen; 5 palladium over charcoal in methanol T=30°C; 3 h;
参考文献
DR. REDDY'S LABORATORIES LTD.; DR. REDDY'S LABORATORIES, INC.
Patent: WO2007/44829 A2, 2007 ;
Location in patent: Page/Page column 43 ;
反应条件
palladium 10 on activated carbon; hydrogen; toluene-4-sulfonic acid in methanol T=20°C; 5 h; Overall yield = 98 percent;
参考文献
Wan, Wei-Li; He, Yun; Guan, Mei; Li, Xiao-Long; Cheng, Xu; Wu, Yong
Chinese Chemical Letters, 2013 , vol. 24, # 12 p. 1118 - 1122
反应条件
1: bis(cyclopentadienyl)dimethyltitanium / toluene / 60 °C 2: palladium 10 on activated carbon; hydrogen; toluene-4-sulfonic acid / methanol / 5 h / 20 °C View Scheme
参考文献
Wan, Wei-Li; He, Yun; Guan, Mei; Li, Xiao-Long; Cheng, Xu; Wu, Yong
Chinese Chemical Letters, 2013 , vol. 24, # 12 p. 1118 - 1122
反应条件
1.1: hydrogen bromide / dimethyl sulfoxide / 80 °C 2.1: acetic acid 2.2: 100 °C 3.1: L-Selectridereg; / tetrahydrofuran / -78 °C 4.1: bis(cyclopentadienyl)dimethyltitanium / toluene / 60 °C 5.1: palladium 10 on activated carbon; hydrogen; toluene-4-sulfonic acid / methanol / 5 h / 20 °C View Scheme
参考文献
Wan, Wei-Li; He, Yun; Guan, Mei; Li, Xiao-Long; Cheng, Xu; Wu, Yong
Chinese Chemical Letters, 2013 , vol. 24, # 12 p. 1118 - 1122
反应条件
1.1: acetic acid 1.2: 100 °C 2.1: L-Selectridereg; / tetrahydrofuran / -78 °C 3.1: bis(cyclopentadienyl)dimethyltitanium / toluene / 60 °C 4.1: palladium 10 on activated carbon; hydrogen; toluene-4-sulfonic acid / methanol / 5 h / 20 °C View Scheme
参考文献
Wan, Wei-Li; He, Yun; Guan, Mei; Li, Xiao-Long; Cheng, Xu; Wu, Yong
Chinese Chemical Letters, 2013 , vol. 24, # 12 p. 1118 - 1122
反应条件
potassium carbonate in water; N,N-dimethyl-formamide T=0°C;
参考文献
Gangula, Srinivas; Elati, Chandrashekhar R.; Mudunuru, Satish Varma; Nardela, Anitha; Dongamanti, Ashok; Bhattacharya, Apurba; Bandichhor, Rakeshwar
Synthetic Communications, 2010 , vol. 40, # 15 p. 2254 - 2268
