(S)-5-羟甲基二氢呋喃-2-酮合成路线 （共 80 条）
反应条件
magnesium chloride in N,N-dimethyl acetamide; water 20 h; Heating;
参考文献
Takano, Seiichi; Goto, Emiko; Hirama, Michiyasu; Ogasawara, Kunio
Heterocycles, 1981 , vol. 16, # 6 p. 951 - 954
反应条件
trifluoroacetic acid in tetrahydrofuran; water 3 h; Ambient temperature;
参考文献
Takano, Seiichi; Kurotaki, Ayako; Takahashi, Michiyasu; Ogasawara, Kunio
Synthesis, 1986 , # 5 p. 403 - 406
反应条件
hydrogen; 5 percent palladium-carbon; palladium dichloride in ethanol P=750.06 Torr;
参考文献
Tetrahedron, , vol. 40, # 8 p. 1303 - 1312
反应条件
sodium tetrahydroborate in ethanol
参考文献
stergaard, Michael E.; Wamberg, Michael C.; Pedersen, Erik B.
Nucleosides, Nucleotides and Nucleic Acids, 2011 , vol. 30, # 3 p. 210 - 226
反应条件
1: 98 percent / aq. HCl / 7 h / Ambient temperature 2: 1.) NaH 3: 93 percent / n-Bu3SnH, AIBN / toluene / Heating 4: 96 percent / TFA / H2O; CHCl3 / 10 h / 70 °C 5: 84 percent / pyridine / 4 h / Ambient temperature 6: 1.) PPh3, DEAD, 2.) MeI / 1.) benzene, rt, 24 h, 2.) toluene, rt, 30 min, reflux, 24 h 7: 60 percent / H2 / Pd/C / ethanol / 12 h / Ambient temperature 8: 77 percent / p-TsOH / methanol / 5 h / Ambient temperature View Scheme
参考文献
Synthetic Communications, , vol. 29, # 12 p. 2187 - 2199
反应条件
sodium tetrahydroborate in methanol T=-30 - -15°C; 1.5 h; Yield given;
参考文献
Journal of Medicinal Chemistry, , vol. 40, # 2 p. 168 - 180
反应条件
(R,R)-(salen)Co(OAc) in water T=20°C; 30 h;
参考文献
Liu, Zhi-Yu; Ji, Jian-Xin; Li, Bo-Gang
Journal of the Chemical Society, Perkin Transactions 1, 2000 , # 20 p. 3519 - 3521
反应条件
trifluoroacetic acid T=-10°C; 0.25 h;
参考文献
Liu, Zhi-Yu; Ji, Jian-Xin; Li, Bo-Gang
Journal of the Chemical Society, Perkin Transactions 1, 2000 , # 20 p. 3519 - 3521
反应条件
(S,S)-[1,2-cyclohexanediamino-N,N'-bis(3,5-di-t-butylsalicylidene)]cobaltIII*OAc in water T=20°C; 30 h; Title compound not separated from byproducts;
参考文献
Liu, Zhi-Yu; Ji, Jian-Xin; Li, Bo-Gang
Journal of the Chemical Society, Perkin Transactions 1, 2000 , # 20 p. 3519 - 3521
反应条件
lipase SP; water in acetone T=35°C; 0.2 h; pH 7.2, phosphate buffer; Title compound not separated from byproducts;
参考文献
Journal of Organic Chemistry, , vol. 63, # 22 p. 8062 - 8066
