(S)-5-羟甲基二氢呋喃-2-酮合成路线 （共 80 条）
反应条件
1: 68 percent / 220 °C / 40 Torr 2: H2 / 10 percent Pd/C / ethyl acetate / 760 Torr View Scheme
参考文献
Tetrahedron, , vol. 38, # 15 p. 2395 - 2402
反应条件
1: 1.) LDA / 1.) THF, HMPA, -78degC, 0.5 h; 2.) -78 degC, 1 h, -20 degC, 4 h, room temp., 19 h 2: 85 percent / methanol; H2O / 0.5 h / Ambient temperature 3: H2 / 5percentPd-C, PdCl2 / ethanol / 750.06 Torr View Scheme
参考文献
Tetrahedron, , vol. 40, # 8 p. 1303 - 1312
反应条件
1: 85 percent / methanol; H2O / 0.5 h / Ambient temperature 2: H2 / 5percentPd-C, PdCl2 / ethanol / 750.06 Torr View Scheme
参考文献
Tetrahedron, , vol. 40, # 8 p. 1303 - 1312
反应条件
1: 95 percent / H2 / 10percent Pd-C / ethanol / 10 h / Ambient temperature 2: 88 percent / trifluoroacetic acid / tetrahydrofuran; H2O / 3 h / Ambient temperature View Scheme
参考文献
Synthesis, , # 5 p. 403 - 406
反应条件
toluene-4-sulfonic acid Cyclization;
参考文献
Yoda, Hidemi; Asai, Fumihito; Takabe, Kunihiko
Synlett, 2000 , # 7 p. 1001 - 1003
反应条件
1: 96 percent / TFA / H2O; CHCl3 / 10 h / 70 °C 2: 84 percent / pyridine / 4 h / Ambient temperature 3: 1.) PPh3, DEAD, 2.) MeI / 1.) benzene, rt, 24 h, 2.) toluene, rt, 30 min, reflux, 24 h 4: 60 percent / H2 / Pd/C / ethanol / 12 h / Ambient temperature 5: 77 percent / p-TsOH / methanol / 5 h / Ambient temperature View Scheme
参考文献
Synthetic Communications, , vol. 29, # 12 p. 2187 - 2199
反应条件
1: 1.) NaH 2: 93 percent / n-Bu3SnH, AIBN / toluene / Heating 3: 96 percent / TFA / H2O; CHCl3 / 10 h / 70 °C 4: 84 percent / pyridine / 4 h / Ambient temperature 5: 1.) PPh3, DEAD, 2.) MeI / 1.) benzene, rt, 24 h, 2.) toluene, rt, 30 min, reflux, 24 h 6: 60 percent / H2 / Pd/C / ethanol / 12 h / Ambient temperature 7: 77 percent / p-TsOH / methanol / 5 h / Ambient temperature View Scheme
参考文献
Synthetic Communications, , vol. 29, # 12 p. 2187 - 2199
反应条件
1: 84 percent / pyridine / 4 h / Ambient temperature 2: 1.) PPh3, DEAD, 2.) MeI / 1.) benzene, rt, 24 h, 2.) toluene, rt, 30 min, reflux, 24 h 3: 60 percent / H2 / Pd/C / ethanol / 12 h / Ambient temperature 4: 77 percent / p-TsOH / methanol / 5 h / Ambient temperature View Scheme
参考文献
Synthetic Communications, , vol. 29, # 12 p. 2187 - 2199
反应条件
1: 1.) PPh3, DEAD, 2.) MeI / 1.) benzene, rt, 24 h, 2.) toluene, rt, 30 min, reflux, 24 h 2: 60 percent / H2 / Pd/C / ethanol / 12 h / Ambient temperature 3: 77 percent / p-TsOH / methanol / 5 h / Ambient temperature View Scheme
参考文献
Synthetic Communications, , vol. 29, # 12 p. 2187 - 2199
反应条件
sodium tetrahydroborate in ethanol; dichloromethane T=-30°C; 0.5 h; Yield given;
参考文献
Farmaco, Edizione Scientifica, , vol. 39, # 5 p. 473 - 476
