(S)-5-羟甲基二氢呋喃-2-酮合成路线 （共 80 条）
反应条件
1: aq. NaIO4, SiO2 / CH2Cl2 / 0.25 h 2: NaBH4 / methanol / 1.5 h / -30 - -15 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 40, # 2 p. 168 - 180
反应条件
1: H2, thriethylamine / Pd/C / ethyl acetate / 76000 Torr / Ambient temperature 2: aq. perchloric acid / 1 h 3: H2, triethylamine / Pd/C / ethyl acetate / 20 h / 76000 Torr / Ambient temperature 4: 1.) KOH, 2.) 2M HCl / 2.) 50 deg C View Scheme
参考文献
Acta Chemica Scandinavica, Series B: Organic Chemistry and Biochemistry, , vol. 35, # 3 p. 155 - 162
反应条件
1: HBr, acetic acid / 1 h / Ambient temperature 2: H2, thriethylamine / Pd/C / ethyl acetate / 76000 Torr / Ambient temperature 3: aq. perchloric acid / 1 h 4: H2, triethylamine / Pd/C / ethyl acetate / 20 h / 76000 Torr / Ambient temperature 5: 1.) KOH, 2.) 2M HCl / 2.) 50 deg C View Scheme
参考文献
Acta Chemica Scandinavica, Series B: Organic Chemistry and Biochemistry, , vol. 35, # 3 p. 155 - 162
反应条件
1: H2, triethylamine / Pd/C / ethyl acetate / 20 h / 76000 Torr / Ambient temperature 2: 1.) KOH, 2.) 2M HCl / 2.) 50 deg C View Scheme
参考文献
Acta Chemica Scandinavica, Series B: Organic Chemistry and Biochemistry, , vol. 35, # 3 p. 155 - 162
反应条件
1: aq. perchloric acid / 1 h 2: H2, triethylamine / Pd/C / ethyl acetate / 20 h / 76000 Torr / Ambient temperature 3: 1.) KOH, 2.) 2M HCl / 2.) 50 deg C View Scheme
参考文献
Acta Chemica Scandinavica, Series B: Organic Chemistry and Biochemistry, , vol. 35, # 3 p. 155 - 162
反应条件
dimethylsulfide borane complex in tetrahydrofuran
参考文献
Tetrahedron Letters, , vol. 36, # 10 p. 1637 - 1640
反应条件
1: tetrahydrofuran / 0.25 h / Ambient temperature 2: Raney nickel / tetrahydrofuran / 4 h / Heating View Scheme
参考文献
Tetrahedron, , vol. 43, # 21 p. 5055 - 5072
反应条件
nickel in tetrahydrofuran 4 h; Heating; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Tetrahedron, , vol. 43, # 21 p. 5055 - 5072
反应条件
1: 93 percent / MCPBA / CH2Cl2 / 6 h 2: (R,R)-(salen)Co(OAc) / H2O / 30 h / 20 °C View Scheme
参考文献
Journal of the Chemical Society, Perkin Transactions 1, , # 20 p. 3519 - 3521
反应条件
1: 90 percent / H2 / Pd/C View Scheme
参考文献
Heterocycles, , vol. 31, # 3 p. 423 - 426
