6-氨基-4-(羟甲基)-4-环己基-[4H,5H]-1,2,3-三醇合成路线 （共 24 条）
反应条件
hydrogen; nickel in water T=20°C; P=2068.59 Torr; 20 h;
参考文献
Dong; Mahmud; Tornus; Lee; Floss
Journal of the American Chemical Society, 2001 , vol. 123, # 12 p. 2733 - 2742
反应条件
N-bromosuccinmide; water in N,N-dimethyl-formamide T=20°C; 8 h;
参考文献
US8101732 B2, ;
Page/Page column 28 ;
反应条件
hydrogenchloride; palladium 10 on activated carbon; hydrogen in methanol; water; ethyl acetate P=760.051 Torr; 20 h;
参考文献
Asamizu, Shumpei; Yang, Jongtae; Almabruk, Khaled H.; Mahmud, Taifo
Journal of the American Chemical Society, 2011 , vol. 133, # 31 p. 12124 - 12135
反应条件
Streptomyces hygroscopicus var. limoneus in water T=28°C; 168 h; Further byproducts.;
参考文献
Journal of the American Chemical Society, , vol. 123, # 12 p. 2733 - 2742
反应条件
Streptomyces hygroscopicus var. limoneus in water T=28°C; 168 h; Further byproducts.;
参考文献
Journal of the American Chemical Society, , vol. 123, # 12 p. 2733 - 2742
反应条件
1: 1.) LiN3, 2.) aq. H2SO4 / 1.) DMF, 105 deg C, 2.5 h, 2.) THF, 50 deg C, 30 min 2: 96 percent / pyridine / CH2Cl2 / 0.5 h / 0 °C 3: 89 percent / tetrahydrofuran / 3 h / 80 °C 4: 98 percent / NaOMe / methanol / 6 h / Ambient temperature 5: H2 / Raney nickel / ethyl acetate / 18 h / Ambient temperature 6: Na, NH3 / tetrahydrofuran / 1.5 h / -40 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 60, # 16 p. 5332 - 5334
反应条件
1: 89 percent / tetrahydrofuran / 3 h / 80 °C 2: 98 percent / NaOMe / methanol / 6 h / Ambient temperature 3: H2 / Raney nickel / ethyl acetate / 18 h / Ambient temperature 4: Na, NH3 / tetrahydrofuran / 1.5 h / -40 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 60, # 16 p. 5332 - 5334
反应条件
1: 96 percent / pyridine / CH2Cl2 / 0.5 h / 0 °C 2: 89 percent / tetrahydrofuran / 3 h / 80 °C 3: 98 percent / NaOMe / methanol / 6 h / Ambient temperature 4: H2 / Raney nickel / ethyl acetate / 18 h / Ambient temperature 5: Na, NH3 / tetrahydrofuran / 1.5 h / -40 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 60, # 16 p. 5332 - 5334
反应条件
1: H2 / Raney nickel / ethyl acetate / 18 h / Ambient temperature 2: Na, NH3 / tetrahydrofuran / 1.5 h / -40 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 60, # 16 p. 5332 - 5334
反应条件
1: 98 percent / NaOMe / methanol / 6 h / Ambient temperature 2: H2 / Raney nickel / ethyl acetate / 18 h / Ambient temperature 3: Na, NH3 / tetrahydrofuran / 1.5 h / -40 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 60, # 16 p. 5332 - 5334
