2-氯-5-三氟甲基苯腈合成路线 （共 20 条）
参考文献
Pfizer Inc.
Patent: US3953595 A1, 1976 ;
反应条件
lithium aluminium tetrahydride in diethyl ether Heating;
参考文献
Short,J.H.; Darby,T.D.
Journal of Medicinal Chemistry, 1967 , vol. 10, p. 833 - 840
反应条件
1: (i) Et2O, benzene, (ii) HCl, (iii) aq. H2SO4, toluene
2: aq. NH3, CuCl / dioxane / 140 °C
View Scheme
参考文献
Saucy,G.; Sternbach,L.H.
Helvetica Chimica Acta, 1962 , vol. 45, p. 2226 - 2241
反应条件
1: 1.) t-BuOK / 1.) DMF, 20-25 deg C, 1 h; 2.) 17 h
2: 1.) acetic acid, 2.) 60 percent aq. H2SO4 / 1.) 100 deg C, 2.) 110 deg C, 6 h
3: N-methylpyrrolidone / 1 h / 100 °C
View Scheme
参考文献
Sommer, Michael Bech; Begtrup, Mikael; Boegesoe, Klaus Peter
Journal of Organic Chemistry, 1990 , vol. 55, # 16 p. 4822 - 4827
反应条件
(i) Et2O, benzene, (ii) HCl, (iii) aq. H2SO4, toluene; Multistep reaction;
参考文献
Saucy,G.; Sternbach,L.H.
Helvetica Chimica Acta, 1962 , vol. 45, p. 2226 - 2241
反应条件
(i) KOH, MeOH, (ii) /BRN= 1912184/, sulfolane; Multistep reaction;
参考文献
Rohm and Haas
Patent: CH567359DE2311638 , 1975 ;
Chem.Abstr., 1974 , vol. 80, # 3253
反应条件
(i) KOH, MeOH, (ii) /BRN= 1912184/, sulfolane; Multistep reaction;
参考文献
Rohm and Haas
Patent: CH567359DE2311638 , 1975 ;
Chem.Abstr., 1974 , vol. 80, # 3253
反应条件
(i) KOH, MeOH, (ii) /BRN= 1912184/, sulfolane; Multistep reaction;
参考文献
Rohm and Haas
Patent: CH567359DE2311638 , 1975 ;
Chem.Abstr., 1974 , vol. 80, # 3253
反应条件
benzyl alcohol in water; dimethyl sulfoxide
参考文献
Pfizer Inc.
Patent: US3953595 A1, 1976 ;
反应条件
hydrogenchloride; sodium hydroxide; benzyl alcohol in diethyl ether; ethanol; water
参考文献
May and Baker Limited
Patent: US4146631 A1, 1979 ;
