in ethanol 2.5 h; Heating; Yield given;

1: KS-Selectride / tetrahydrofuran / 2 h / -78 °C 2: 31 percent / lipase Meito SL / diisopropyl ether / 46 h / 35 °C 3: 93 percent / K2CO3 / methanol / 2 h / -20 - 0 °C 4: 96 percent / NaN3; NH4Cl / H2O; acetone / 23 h / Heating 5: DMAP / CH2Cl2 / 4 h / 20 °C 6: H2 / 10 percent Pd/C / methanol / 48 h / 20 °C / 760 Torr 7: 90 percent / DEAD; PPh3 / benzene / 20 h / 20 °C 8: 90 percent / 1N aq. HCl / methanol / 2 h / Heating View Scheme

in chloroform Heating;

1: 73 percent / hydrazine hydrate / methanol / 8 h / Heating 2: 98 percent / 0.08 h / 170 - 175 °C View Scheme

1: phenylchloropyruvic acid methyl ester; N-(4-methyl-2-pyridinyl)-N'-phenyl thiourea in dichloromethane 5 h; 2: 1,2-diamino-benzene With acetic acid 1 h; Heating; Further stages.;

1: phenylchloropyruvic acid methyl ester; 1-(3-methylpyridin-2-yl)-3-phenylthiourea in dichloromethane 5 h; 2: 1,2-diamino-benzene With acetic acid 1 h; Heating; Further stages.;

1: 1-phenyl-3-(pyridin-2-yl)thiourea; phenylchloropyruvic acid methyl ester in dichloromethane 5 h; 2: 1,2-diamino-benzene With acetic acid 1 h; Heating; Further stages.;

1.1: acetonitrile / 5 h / Molecular sieve 1.2: 6 h / 50 °C 2.1: sodium hydroxide; water / tetrahydrofuran; methanol / 3 h 2.2: pH 3 - 4 / Cooling with ice View Scheme

1: 12 percent / ethanol / Heating 2: methanol / 2 h / Heating View Scheme

in methanol 1.5 h; Heatingother ester, other sodium alcoholate;