2-二氮杂-1-苯乙酮合成路线 （共 259 条）
反应条件
1: 1.) BF3-etherat, 2.) 4-toluenesulfonic acid / 1.) benzene, 15 deg C, 2.) dioxane, reflux, 6 h
2: NH3 / ethanol / 12 h / 5 °C
View Scheme
参考文献
Bartsch
Archiv der Pharmazie, 1982 , vol. 315, # 8 p. 684 - 691
反应条件
1: 1.) BF3-etherat, 2.) 4-toluenesulfonic acid / 1.) benzene, 15 deg C, 2.) dioxane, reflux, 6 h
2: H2 / Pd/C / ethanol / 0.25 h
View Scheme
参考文献
Bartsch
Archiv der Pharmazie, 1982 , vol. 315, # 8 p. 684 - 691
反应条件
1: 1.) BF3-etherat, 2.) 4-toluenesulfonic acid / 1.) benzene, 15 deg C, 2.) dioxane, reflux, 6 h
2: H2, NH3 / Pd/C / ethanol
View Scheme
参考文献
Bartsch
Archiv der Pharmazie, 1982 , vol. 315, # 8 p. 684 - 691
参考文献
King; Miller
Journal of the American Chemical Society, 1948 , vol. 70, p. 4154
反应条件
copper(II) bis(trifluoromethanesulfonate) in 1,2-dichloro-ethane
T=80°C; 2.5 h;
参考文献
Yadav; Subba Reddy; Gopal Rao; Srinivas; Narsaiah
Tetrahedron Letters, 2007 , vol. 48, # 43 p. 7717 - 7720
反应条件
boron trifluoride diethyl etherate
T=50°C; 4 h;
参考文献
Doyle, Michael P.; Trudell, Mark L.
Journal of Organic Chemistry, 1984 , vol. 49, # 7 p. 1196 - 1199
反应条件
copper(II) bis(trifluoromethanesulfonate)
T=50°C; 4 h; also with BF3*Et2O as catalyst; Product distribution;
参考文献
Doyle, Michael P.; Trudell, Mark L.
Journal of Organic Chemistry, 1984 , vol. 49, # 7 p. 1196 - 1199
反应条件
boron trifluoride diethyl etherate
参考文献
Ibata,T.; Sato,R.
Chemistry Letters, 1978 , p. 1129 - 1130
反应条件
copper in xylene
T=90°C; 24 h;
参考文献
Pellicciari; Curini; Spagnoli
Archiv der Pharmazie, 1984 , vol. 317, # 1 p. 38 - 41
反应条件
1.1: indium trifluoromethanesulfonate / toluene / 20 °C / Inert atmosphere
2.1: lithium hexamethyldisilazane / tetrahydrofuran; cyclohexane / 1 h / -78 °C / Inert atmosphere
2.2: 1 h / -78 - 20 °C / Inert atmosphere
3.1: potassium tert-butylate / tetrahydrofuran / 0.33 h / -78 °C / Inert atmosphere
4.1: toluene / 1 h / 60 °C / Inert atmosphere
View Scheme
参考文献
Tudjarian, Armen A.; Minehan, Thomas G.
Journal of Organic Chemistry, 2011 , vol. 76, # 9 p. 3576 - 3581
