5-甲基吡咯-2-甲酸乙酯合成路线 （共 27 条）
反应条件
sodium ethanolate 0.5 h; Ambient temperature;
参考文献
Molins-Pujol, Antoni M.; Moranta, Concepcio; Arroyo, Carmina; Rodriguez, M. Teresa; Meca, M. Carmen; Pujol, M. Dolors; Bonal, Joaquim
Journal of the Chemical Society - Perkin Transactions 1, 1996 , # 18 p. 2277 - 2289
反应条件
1: ethyl acetate With sodium nitrate; acetic acid in water T=0°C; 2: 4,4-dimethoxy-butan-2-one With zinc T=60 - 120°C; 8.33 h;
参考文献
WO2010/67125 A1, ;
Page/Page column 70-71 ;
WO 2010/067125 A1
反应条件
sodium ethanolate in ethanol 2 h; Heating;
参考文献
Curran, Timothy P.; Keaney, Meghan T.
Journal of Organic Chemistry, 1996 , vol. 61, # 25 p. 9068 - 9069
反应条件
1: With sodium nitrite 2: With zinc Further stages.;
参考文献
Gale, Philip A.; Navakhun, Korakot; Camiolo, Salvatore; Light, Mark E.; Hursthouse, Michael B.
Journal of the American Chemical Society, 2002 , vol. 124, # 38 p. 11228 - 11229
反应条件
2,2'-azo-bisisobutyronitrile in n-heptane; chlorobenzene Heating;
参考文献
Quiclet-Sire, Beatrice; Wendeborn, Frederique; Zard, Samir Z.
Chemical Communications, 2002 , # 19 p. 2214 - 2215
参考文献
WO2006/92608 A1, ;
Page/Page column 54 ;
WO 2006/092608 A1
反应条件
1: H2, 2M HCl / Pd/C / ethanol / Ambient temperature 2: 2M HCl / ethanol / 16 h View Scheme
参考文献
Synthetic Communications, , vol. 19, # 5and6 p. 763 - 768
反应条件
diethyl ether; N,N-dimethyl-aniline anschliessend Behandeln mit Aethanol und weiterem N,N-Dimethyl-anilin;
参考文献
Justus Liebigs Annalen der Chemie, , vol. 615, p. 137,163
反应条件
1: triethylamine / CH2Cl2 / 0 °C 2: 45 percent / Pd(PPh3)4, Et3N / dimethylformamide / 1 h / 80 °C View Scheme
参考文献
Chemistry Letters, , # 1 p. 45 - 46
反应条件
pyridine; 1,8-diazabicyclo[5.4.0]undec-7-ene; trichlorophosphate 1) r.t. 2) THF, reflux; Yield given. Multistep reaction;
参考文献
Journal of Heterocyclic Chemistry, , vol. 28, # 7 p. 1671 - 1676
