2-(4-氨基苯基)丙酸乙酯合成路线 （共 21 条）
反应条件
hydrogen; palladium on activated charcoal in methanol T=20°C;
参考文献
Lawrence, Nicholas J.; Liddle, John; Bushell, Simon M.; Jackson, David A.
Journal of Organic Chemistry, 2002 , vol. 67, # 2 p. 457 - 464
反应条件
toluene-4-sulfonic acid in toluene 18 h; Heating;
参考文献
Takahashi, Ichiro; Hirano, Etsushi; Kawakami, Teruki; Kitajima, Hidehiko
Heterocycles, 1996 , vol. 43, # 11 p. 2343 - 2346
反应条件
1: 93 percent / H2 / 5percent Pd-C / ethanol / 0.75 h / 36775.4 Torr / Ambient temperature 2: 96 percent / p-TsOH / toluene / 18 h / Heating View Scheme
参考文献
Nannini; Giraldi; Molgora; Biasoli; Spinelli; Logemann; Dradi; Zanni; Buttinoni; Tommasini
Arzneimittel-Forschung/Drug Research, 1973 , vol. 23, # 8 p. 1090 - 1100
反应条件
hydrazine hydrate in ethanol T=20°C; 18 h;
参考文献
Yoshikawa, Kenji; Yoshino, Toshiharu; Yokomizo, Yoshihiro; Uoto, Kouichi; Naito, Hiroyuki; Kawakami, Katsuhiro; Mochizuki, Akiyoshi; Nagata, Tsutomu; Suzuki, Makoto; Kanno, Hideyuki; Takemura, Makoto; Ohta, Toshiharu
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 7 p. 2133 - 2140
反应条件
1: aq. H2SO4 2: H2SO4 3: H2 / Pd-C / ethanol View Scheme
参考文献
Nannini; Giraldi; Molgora; Biasoli; Spinelli; Logemann; Dradi; Zanni; Buttinoni; Tommasini
Arzneimittel-Forschung/Drug Research, 1973 , vol. 23, # 8 p. 1090 - 1100
反应条件
1: HNO3 2: aq. H2SO4 3: H2SO4 4: H2 / Pd-C / ethanol View Scheme
参考文献
Nannini; Giraldi; Molgora; Biasoli; Spinelli; Logemann; Dradi; Zanni; Buttinoni; Tommasini
Arzneimittel-Forschung/Drug Research, 1973 , vol. 23, # 8 p. 1090 - 1100
反应条件
3: 1) H2NOH*HCl / 1) EtOH, heating, 2) EtOH, H+ View Scheme
参考文献
Bruekelman, Stephen P.; Leach, (Miss) Susan E.; Meakins, G. Denis; Tirel, Malcolm D.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1984 , p. 2801 - 2807
反应条件
2: 1) H2NOH*HCl / 1) EtOH, heating, 2) EtOH, H+ View Scheme
参考文献
Bruekelman, Stephen P.; Leach, (Miss) Susan E.; Meakins, G. Denis; Tirel, Malcolm D.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1984 , p. 2801 - 2807
反应条件
1.1: acetic acid / 18 h / Reflux 2.1: sodium hydride / N,N-dimethyl-formamide / 1 h / 0 - 20 °C 2.2: 2 h / 0 - 20 °C 3.1: hydrazine hydrate / ethanol / 18 h / 20 °C View Scheme
参考文献
Yoshikawa, Kenji; Yoshino, Toshiharu; Yokomizo, Yoshihiro; Uoto, Kouichi; Naito, Hiroyuki; Kawakami, Katsuhiro; Mochizuki, Akiyoshi; Nagata, Tsutomu; Suzuki, Makoto; Kanno, Hideyuki; Takemura, Makoto; Ohta, Toshiharu
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 7 p. 2133 - 2140
反应条件
1.1: sodium hydride / N,N-dimethyl-formamide / 1 h / 0 - 20 °C 1.2: 2 h / 0 - 20 °C 2.1: hydrazine hydrate / ethanol / 18 h / 20 °C View Scheme
参考文献
Yoshikawa, Kenji; Yoshino, Toshiharu; Yokomizo, Yoshihiro; Uoto, Kouichi; Naito, Hiroyuki; Kawakami, Katsuhiro; Mochizuki, Akiyoshi; Nagata, Tsutomu; Suzuki, Makoto; Kanno, Hideyuki; Takemura, Makoto; Ohta, Toshiharu
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 7 p. 2133 - 2140
