2-(4-氨基苯基)丙酸乙酯合成路线 （共 21 条）
反应条件
sulfuric acid in ethanol 3 h; Heating; Yield given;
参考文献
Bruekelman, Stephen P.; Leach, (Miss) Susan E.; Meakins, G. Denis; Tirel, Malcolm D.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1984 , p. 2801 - 2807
反应条件
1: 83 percent / n-BuLi, i-Pr2NH / hexane; tetrahydrofuran / 1.) -25 deg C, 70 min, 2.) 2 h 2: H2NOH*HCl / ethanol; H2O / 24 h / Heating 3: H2SO4 / ethanol / 3 h / Heating View Scheme
参考文献
Bruekelman, Stephen P.; Leach, (Miss) Susan E.; Meakins, G. Denis; Tirel, Malcolm D.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1984 , p. 2801 - 2807
反应条件
1: 88 percent / AcOH / benzene / 4 h / Heating 2: 83 percent / n-BuLi, i-Pr2NH / hexane; tetrahydrofuran / 1.) -25 deg C, 70 min, 2.) 2 h 3: H2NOH*HCl / ethanol; H2O / 24 h / Heating 4: H2SO4 / ethanol / 3 h / Heating View Scheme
参考文献
Bruekelman, Stephen P.; Leach, (Miss) Susan E.; Meakins, G. Denis; Tirel, Malcolm D.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1984 , p. 2801 - 2807
反应条件
1: 74 percent / n-BuLi / hexane; tetrahydrofuran / 1.) -20 deg C --> 0 deg C, 45 min, 2.) 12 h 2: HgCl2 / methanol; H2O / 4 h / Heating 3: KOH / methanol / 2 h / Heating 4: 83 percent / n-BuLi, i-Pr2NH / hexane; tetrahydrofuran / 1.) -25 deg C, 70 min, 2.) 2 h 5: H2NOH*HCl / ethanol; H2O / 24 h / Heating 6: H2SO4 / ethanol / 3 h / Heating View Scheme
参考文献
Bruekelman, Stephen P.; Leach, (Miss) Susan E.; Meakins, G. Denis; Tirel, Malcolm D.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1984 , p. 2801 - 2807
反应条件
1: H2NOH*HCl / ethanol; H2O / 24 h / Heating 2: H2SO4 / ethanol / 3 h / Heating View Scheme
参考文献
Bruekelman, Stephen P.; Leach, (Miss) Susan E.; Meakins, G. Denis; Tirel, Malcolm D.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1984 , p. 2801 - 2807
反应条件
1: 96 percent / AcOH / benzene / 4 h / Heating 2: 93 percent / n-BuLi / hexane; diethyl ether / 1.) -20 deg C, 50 min, 2.) - 20 deg C, 1 h, 3.) 2 h 3: 74 percent / n-BuLi / hexane; tetrahydrofuran / 1.) -20 deg C --> 0 deg C, 45 min, 2.) 12 h 4: HgCl2 / methanol; H2O / 4 h / Heating 5: KOH / methanol / 2 h / Heating 6: 83 percent / n-BuLi, i-Pr2NH / hexane; tetrahydrofuran / 1.) -25 deg C, 70 min, 2.) 2 h 7: H2NOH*HCl / ethanol; H2O / 24 h / Heating 8: H2SO4 / ethanol / 3 h / Heating View Scheme
参考文献
Bruekelman, Stephen P.; Leach, (Miss) Susan E.; Meakins, G. Denis; Tirel, Malcolm D.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1984 , p. 2801 - 2807
反应条件
hydroxylamine hydrochloride 1) EtOH, heating, 2) EtOH, H+; Yield given. Multistep reaction;
参考文献
Breukelman, Stephen P.; Meakins, G. Denis; Tirel, Malcolm D.
Journal of the Chemical Society, Chemical Communications, 1982 , # 14 p. 800 - 801
反应条件
1: 68 percent / 2-mercaptoethanol; benzo-1,2,3-1H-triazole / acetonitrile; H2O; various solvent(s) / 13 h 2: 75 percent / NaOH / ethanol / 2.5 h / Heating View Scheme
参考文献
Takahashi, Ichiro; Hirano, Etsushi; Kawakami, Teruki; Kitajima, Hidehiko
Heterocycles, 1996 , vol. 43, # 11 p. 2343 - 2346
反应条件
triethyl phosphite
1.) methanol, 4 h, reflux; 2.) 8 h, 150 deg C; Yield given. Multistep reaction;
参考文献
Picciola; Ravenna; Carenini; Gentili; Riva
Farmaco, Edizione Scientifica, 1981 , vol. 36, # 12 p. 1037 - 1056
反应条件
1: 1.) NaNO2; 2.) K2CO3; 3.) CuCN / 1.) 6M HCl, H2O, 0-5 deg C, 15 min; 2.) 0-5 deg C; 3.) water, 110 deg C, 25 min
2: 57 percent / Raney-alloy / formic acid / 1 h / Heating
3: 88 percent / NaBH4 / methanol; H2O / 20 - 22 °C
4: 92 percent / 12M HCl / 0.5 h / Ambient temperature
View Scheme
参考文献
Biagi; Livi; Scartoni; Verugi
Farmaco, Edizione Scientifica, 1988 , vol. 43, # 7-8 p. 597 - 611
